Patrick S Stumpf
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Explore the profile of Patrick S Stumpf including associated specialties, affiliations and a list of published articles.
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22
Citations
352
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Recent Articles
11.
Fidanza A, Stumpf P, Ramachandran P, Tamagno S, Babtie A, Lopez-Yrigoyen M, et al.
Blood
. 2020 Jul;
136(25):2893-2904.
PMID: 32614947
Hematopoietic stem and progenitor cells (HSPCs) develop in distinct waves at various anatomical sites during embryonic development. The in vitro differentiation of human pluripotent stem cells (hPSCs) recapitulates some of...
12.
Casey M, Stumpf P, MacArthur B
Wiley Interdiscip Rev Syst Biol Med
. 2019 Dec;
12(2):e1471.
PMID: 31828979
Cell fate decisions are controlled by complex intracellular molecular regulatory networks. Studies increasingly reveal the scale of this complexity: not only do cell fate regulatory networks contain numerous positive and...
13.
Stumpf P, MacArthur B
Front Genet
. 2019 Feb;
10:2.
PMID: 30723489
The molecular regulatory network underlying stem cell pluripotency has been intensively studied, and we now have a reliable ensemble model for the "average" pluripotent cell. However, evidence of significant cell-to-cell...
14.
Nakamura-Ishizu A, Matsumura T, Stumpf P, Umemoto T, Takizawa H, Takihara Y, et al.
Cell Rep
. 2018 Nov;
25(7):1772-1785.e6.
PMID: 30428347
During acute myelosuppression or thrombocytopenia, bone marrow (BM) hematopoietic cells respond rapidly to replenish peripheral blood platelets. While the cytokine thrombopoietin (Thpo) both regulates platelet production and maintains HSC potential,...
15.
Stumpf P, Smith R, Lenz M, Schuppert A, Muller F, Babtie A, et al.
Cell Syst
. 2017 Sep;
5(3):268-282.e7.
PMID: 28957659
Pluripotent stem cells can self-renew in culture and differentiate along all somatic lineages in vivo. While much is known about the molecular basis of pluripotency, the mechanisms of differentiation remain...
16.
Smith R, Stumpf P, Ridden S, Sim A, Filippi S, Harrington H, et al.
Biophys J
. 2017 Jun;
112(12):2641-2652.
PMID: 28636920
A number of important pluripotency regulators, including the transcription factor Nanog, are observed to fluctuate stochastically in individual embryonic stem cells. By transiently priming cells for commitment to different lineages,...
17.
Scarpa E, Bailey J, Janeczek A, Stumpf P, Johnston A, Oreffo R, et al.
Sci Rep
. 2016 Jul;
6:29460.
PMID: 27404770
Polymersome nanoparticles (PMs) are attractive candidates for spatio-temporal controlled delivery of therapeutic agents. Although many studies have addressed cellular uptake of solid nanoparticles, there is very little data available on...
18.
Stumpf P, Ewing R, MacArthur B
Proteomics
. 2016 Jul;
16(17):2303-12.
PMID: 27357612
Pluripotent stem cells (PSCs) are a popular model system for investigating development, tissue regeneration, and repair. Although much is known about the molecular mechanisms that regulate the balance between self-renewal...
19.
Cheung K, Sposito N, Stumpf P, Wilson D, Sanchez-Elsner T, Oreffo R
PLoS One
. 2014 Jun;
9(6):e98063.
PMID: 24892945
MicroRNAs (miRs) play a pivotal role in a variety of biological processes including stem cell differentiation and function. Human foetal femur derived skeletal stem cells (SSCs) display enhanced proliferation and...
20.
Stumpf P, MacArthur B
Methods Mol Biol
. 2014 Apr;
1150:131-9.
PMID: 24743994
The potential gains from advances in high-throughput experimental molecular biology techniques are commonly not fully realized since these techniques often produce more data than can be easily organized and visualized....