Patrick S Stumpf
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Explore the profile of Patrick S Stumpf including associated specialties, affiliations and a list of published articles.
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22
Citations
352
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Recent Articles
1.
Nakashima K, Kunisaki Y, Hosokawa K, Gotoh K, Yao H, Yuta R, et al.
Commun Biol
. 2023 Sep;
6(1):996.
PMID: 37773433
Protection of telomeres 1a (POT1a) is a telomere binding protein. A decrease of POT1a is related to myeloid-skewed haematopoiesis with ageing, suggesting that protection of telomeres is essential to sustain...
2.
Hettige N, Fleming P, Semenak A, Zhang X, Peng H, Hagel M, et al.
Hum Mol Genet
. 2023 May;
32(15):2511-2522.
PMID: 37216650
FOXG1 is a critical transcription factor in human brain where loss-of-function mutations cause a severe neurodevelopmental disorder, while increased FOXG1 expression is frequently observed in glioblastoma. FOXG1 is an inhibitor...
3.
Matthews E, Lanham S, White K, Kyriazi M, Alexaki K, El-Sagheer A, et al.
J Tissue Eng
. 2023 May;
14:20417314231169375.
PMID: 37216034
There is a wealth of data indicating human bone marrow contains skeletal stem cells (SSC) with the capacity for osteogenic, chondrogenic and adipogenic differentiation. However, current methods to isolate SSCs...
4.
Jefri M, Zhang X, Stumpf P, Zhang L, Peng H, Hettige N, et al.
Hum Mol Genet
. 2022 May;
31(21):3715-3728.
PMID: 35640156
Kabuki syndrome is frequently caused by loss-of-function mutations in one allele of histone 3 lysine 4 (H3K4) methyltransferase KMT2D and is associated with problems in neurological, immunological and skeletal system...
5.
Harrington J, Esteban L, Butement J, Vallejo A, Lane S, Sheth B, et al.
Lab Chip
. 2021 Jul;
21(17):3378-3386.
PMID: 34240097
The future of single cell diversity screens involves ever-larger sample sizes, dictating the need for higher throughput methods with low analytical noise to accurately describe the nature of the cellular...
6.
Bell S, McCarty V, Peng H, Jefri M, Hettige N, Antonyan L, et al.
Stem Cell Reports
. 2021 Jul;
16(7):1749-1762.
PMID: 34214487
Mutations in HPRT1, a gene encoding a rate-limiting enzyme for purine salvage, cause Lesch-Nyhan disease which is characterized by self-injury and motor impairments. We leveraged stem cell and genetic engineering...
7.
Stumpf P, Arai F, MacArthur B
Cell Stem Cell
. 2021 Feb;
28(2):187-190.
PMID: 33545078
Epigenetic memories play an important part in regulating stem cell identities. Tools from the theory of non-Markov processes may help us understand these memories better and develop a more integrated...
8.
Arai F, Stumpf P, Ikushima Y, Hosokawa K, Roch A, Lutolf M, et al.
Cell Syst
. 2020 Dec;
11(6):640-652.e5.
PMID: 33296684
Changes in stem cell activity may underpin aging. However, these changes are not completely understood. Here, we combined single-cell profiling with machine learning and in vivo functional studies to explore...
9.
Stumpf P, Du X, Imanishi H, Kunisaki Y, Semba Y, Noble T, et al.
Commun Biol
. 2020 Dec;
3(1):736.
PMID: 33277618
Biomedical research often involves conducting experiments on model organisms in the anticipation that the biology learnt will transfer to humans. Previous comparative studies of mouse and human tissues were limited...
10.
Stumpf P, Arai F, MacArthur B
Phys Biol
. 2020 Nov;
17(6):065013.
PMID: 33210617
Modern single cell experiments have revealed unexpected heterogeneity in apparently functionally 'pure' cell populations. However, we are still lacking a conceptual framework to understand this heterogeneity. Here, we propose that...