Patrick S Daugherty
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Explore the profile of Patrick S Daugherty including associated specialties, affiliations and a list of published articles.
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63
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1542
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Recent Articles
1.
Haynes W, Kamath K, Bozekowski J, Baum-Jones E, Campbell M, Casanovas-Massana A, et al.
Commun Biol
. 2021 Nov;
4(1):1317.
PMID: 34811480
As Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to spread, characterization of its antibody epitopes, emerging strains, related coronaviruses, and even the human proteome in naturally infected patients can...
2.
Paull M, Bozekowski J, Daugherty P
J Immunol Methods
. 2021 Nov;
499:113178.
PMID: 34757083
A more complete understanding of antibody epitopes would aid the development of diagnostics, therapeutic antibodies, and vaccines. However, current methods for mapping antibody binding to epitopes require a targeted experimental...
3.
Haynes W, Kamath K, Waitz R, Daugherty P, Shon J
Front Immunol
. 2021 May;
12:625311.
PMID: 33986742
Identification of the antigens associated with antibodies is vital to understanding immune responses in the context of infection, autoimmunity, and cancer. Discovering antigens at a proteome scale could enable broader...
4.
Wang K, Dropulic L, Bozekowski J, Pietz H, Jegaskanda S, Dowdell K, et al.
J Infect Dis
. 2021 Mar;
224(9):1509-1519.
PMID: 33718970
Previous herpes simplex virus type 2 (HSV-2) vaccines have not prevented genital herpes. Concerns have been raised about the choice of antigen, the type of antibody induced by the vaccine,...
5.
Reifert J, Kamath K, Bozekowski J, Lis E, Horn E, Granger D, et al.
J Clin Microbiol
. 2020 Nov;
59(2).
PMID: 33148704
Widely employed diagnostic antibody serology for Lyme disease, known as standard two-tier testing (STTT), exhibits insufficient sensitivity in early Lyme disease, yielding many thousands of false-negative test results each year....
6.
Chen W, Haynes W, Waitz R, Kamath K, Vega-Crespo A, Shrestha R, et al.
Clin Cancer Res
. 2020 Sep;
26(23):6204-6214.
PMID: 32967941
Purpose: Autoantibody responses in cancer are of great interest, as they may be concordant with T-cell responses to cancer antigens or predictive of response to cancer immunotherapies. Thus, we sought...
7.
Kamath K, Reifert J, Johnston T, Gable C, Pantazes R, Rivera H, et al.
Sci Rep
. 2020 Mar;
10(1):5294.
PMID: 32210339
The detection of pathogen-specific antibodies remains a cornerstone of clinical diagnostics. Yet, many test exhibit undesirable performance or are completely lacking. Given this, we developed serum epitope repertoire analysis (SERA),...
8.
Yoo J, Daugherty P, OMalley M
Nat Commun
. 2020 Feb;
11(1):690.
PMID: 32019920
Epistasis emerges when the effects of an amino acid depend on the identities of interacting residues. This phenomenon shapes fitness landscapes, which have the power to reveal evolutionary paths and...
9.
Paull M, Johnston T, Ibsen K, Bozekowski J, Daugherty P
PLoS One
. 2019 Sep;
14(9):e0217668.
PMID: 31490930
Antibodies are essential to functional immunity, yet the epitopes targeted by antibody repertoires remain largely uncharacterized. To aid in characterization, we developed a generalizable strategy to predict antibody-binding epitopes within...
10.
Ballew J, Reifert J, Daugherty P
Methods Mol Biol
. 2018 May;
1785:249-268.
PMID: 29714024
Antigen discovery and mapping strategies that enable the precise identification of serum antibody-binding epitopes in human diseases will be invaluable for translational diagnostics and therapeutic development. Protein and peptide library...