Patrick R ONeill
Overview
Explore the profile of Patrick R ONeill including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
327
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0
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Recent Articles
1.
Aguirre C, Woo J, Romero-Sosa J, Rivera Z, Tejada A, Munier J, et al.
bioRxiv
. 2023 Apr;
PMID: 37066321
Reversal learning measures the ability to form flexible associations between choice outcomes with stimuli and actions that precede them. This type of learning is thought to rely on several cortical...
2.
Copits B, Gowrishankar R, ONeill P, Li J, Girven K, Yoo J, et al.
Neuron
. 2021 May;
109(11):1791-1809.e11.
PMID: 33979635
Optical manipulations of genetically defined cell types have generated significant insights into the dynamics of neural circuits. While optogenetic activation has been relatively straightforward, rapid and reversible synaptic inhibition has...
3.
Mann A, Mouledous L, Froment C, ONeill P, Dasgupta P, Gunther T, et al.
Sci Signal
. 2019 Mar;
12(574).
PMID: 30914485
Agonists of the nociceptin/orphanin FQ opioid peptide (NOP) receptor, a member of the opioid receptor family, are under active investigation as novel analgesics, but their modes of signaling are less...
4.
Meshik X, ONeill P, Gautam N
ACS Synth Biol
. 2019 Feb;
8(3):498-510.
PMID: 30764607
Cells experience physical deformations to the plasma membrane that can modulate cell behaviors like migration. Understanding the molecular basis for how physical cues affect dynamic cellular responses requires new approaches...
5.
ONeill P, Castillo-Badillo J, Meshik X, Kalyanaraman V, Melgarejo K, Gautam N
Dev Cell
. 2018 Jun;
46(1):9-22.e4.
PMID: 29937389
Cells migrate by applying rearward forces against extracellular media. It is unclear how this is achieved in amoeboid migration, which lacks adhesions typical of lamellipodia-driven mesenchymal migration. To address this...
6.
Meshik X, ONeill P, Gautam N
Methods Mol Biol
. 2018 Mar;
1749:313-324.
PMID: 29526006
Subcellular optogenetics allows specific proteins to be optically activated or inhibited at a restricted subcellular location in intact living cells. It provides unprecedented control of dynamic cell behaviors. Optically modulating...
7.
ONeill P, Kalyanaraman V, Gautam N
Mol Biol Cell
. 2016 Mar;
27(9):1442-50.
PMID: 26941336
Migratory immune cells use intracellular signaling networks to generate and orient spatially polarized responses to extracellular cues. The monomeric G protein Cdc42 is believed to play an important role in...
8.
Karunarathne W, ONeill P, Gautam N
J Cell Sci
. 2014 Nov;
128(1):15-25.
PMID: 25433038
Variation in signaling activity across a cell plays a crucial role in processes such as cell migration. Signaling activity specific to organelles within a cell also likely plays a key...
9.
ONeill P, Gautam N
Mol Biol Cell
. 2014 Jun;
25(15):2305-14.
PMID: 24920824
Cells sense gradients of extracellular cues and generate polarized responses such as cell migration and neurite initiation. There is static information on the intracellular signaling molecules involved in these responses,...
10.
ONeill P, Giri L, Karunarathne W, Patel A, Venkatesh K, Gautam N
Wiley Interdiscip Rev Syst Biol Med
. 2014 Apr;
6(1):115-23.
PMID: 24741711
G-protein-coupled receptors (GPCRs) stimulate signaling networks that control a variety of critical physiological processes. Static information on the map of interacting signaling molecules at the basis of many cellular processes...