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Patrick OConnell

Explore the profile of Patrick OConnell including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 18
Citations 137
Followers 0
Related Specialties
Allergy & Immunology
Neurology
Pharmacology
Top 10 Co-Authors
Yasser A Aldhamen
Andrea Amalfitano
Maja K Blake
Sarah Godbehere
Yuliya Pepelyayeva
Sean Hyslop
David P W Rastall
Cristiane Pereira-Hicks
Ariana M Angarita
Cobi J Heijnen
Published In
J Immunol
Mol Ther
N Engl J Med
Hum Vaccin Immunother
J Neuroinflammation
Affiliations
Soon will be listed here.
Recent Articles
11.
SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment
OConnell P, Hyslop S, Blake M, Godbehere S, Amalfitano A, Aldhamen Y
J Immunol . 2020 Dec; 206(1):193-205. PMID: 33288545
T cell exhaustion represents one of the most pervasive strategies tumors employ to circumvent the immune system. Although repetitive, cognate TCR signaling is recognized as the primary driving force behind...
12.
Systemic innate and adaptive immune responses to SARS-CoV-2 as it relates to other coronaviruses
OConnell P, Aldhamen Y
Hum Vaccin Immunother . 2020 Sep; 16(12):2980-2991. PMID: 32878546
The deadly pandemic caused by the novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) represents one of the greatest threats humanity has faced in the last century. Infection with...
13.
Infection of Primary Human Monocytes with HIV-1
OConnell P, Zheng Y, Amalfitano A, Aldhamen Y
Bio Protoc . 2020 Feb; 9(13). PMID: 32002449
Monocyte infection by HIV-1 is an important component of chronic HIV pathogenesis. Following infection by HIV-1, monocytes are able to cross the blood brain barrier and set up a viral...
14.
SLAM Family Receptor Signaling in Viral Infections: HIV and Beyond
OConnell P, Amalfitano A, Aldhamen Y
Vaccines (Basel) . 2019 Nov; 7(4). PMID: 31744090
The signaling lymphocytic activation molecule (SLAM) family of receptors are expressed on the majority of immune cells. These receptors often serve as self-ligands, and play important roles in cellular communication...
15.
SLAMF7 Is a Critical Negative Regulator of IFN-α-Mediated CXCL10 Production in Chronic HIV Infection
OConnell P, Pepelyayeva Y, Blake M, Hyslop S, Crawford R, Rizzo M, et al.
J Immunol . 2018 Dec; 202(1):228-238. PMID: 30530590
Current advances in combined antiretroviral therapy have rendered HIV infection a chronic, manageable disease; however, the problem of persistent immune activation still remains despite treatment. The immune cell receptor SLAMF7...
16.
ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis
Pepelyayeva Y, Rastall D, Aldhamen Y, OConnell P, Raehtz S, Alyaqoub F, et al.
Sci Rep . 2018 Aug; 8(1):12464. PMID: 30127455
Ankylosing spondylitis (AS) is a prototypical sero-negative autoimmune disease that affects millions worldwide. Single nucleotide polymorphisms in the Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) gene have been linked to AS via...
17.
Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality
Rastall D, Alyaquob F, OConnell P, Pepelyayeva Y, Peters D, Godbehere-Roosa S, et al.
Int Immunol . 2017 Aug; 29(6):277-289. PMID: 28814066
Specific variants of endoplasmic reticulum-associated aminopeptidase 1 (ERAP1) identified by genome-wide association study modify the risk for developing ankylosing spondylitis. We previously confirmed that disease-associated ERAP1 variants have altered enzymatic...
18.
Religion, conscience, and controversial clinical practices
OConnell P, Mistrot J
N Engl J Med . 2007 May; 356(18):1889-92. PMID: 17479480
No abstract available.