Patrick O Helmer
Overview
Explore the profile of Patrick O Helmer including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
227
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Recent Articles
1.
Schmid R, Heuckeroth S, Korf A, Smirnov A, Myers O, Dyrlund T, et al.
Nat Biotechnol
. 2023 Mar;
41(4):447-449.
PMID: 36859716
No abstract available.
2.
Blume B, Schwantes V, Witting M, Hayen H, Schmitt-Kopplin P, Helmer P, et al.
J Proteome Res
. 2023 Jan;
22(3):837-850.
PMID: 36594972
Parkinson's disease (PD) progresses with the loss of dopaminergic neurons in the substantia nigra pars compacta region of the brain. The superior mechanisms and the cause of this specific localized...
3.
Scholz J, Helmer P, Nicolai M, Bornhorst J, Hayen H
J Chromatogr A
. 2021 Aug;
1655:462481.
PMID: 34455370
Sphingolipids exert important functions in cells, ranging from stabilising the cell membrane to bioactive signalling in signal transduction pathways. Changed concentrations of sphingolipids are associated with, among others, neurodegenerative and...
4.
Helmer P, Nordhorn I, Korf A, Behrens A, Buchholz R, Zubeil F, et al.
Anal Chem
. 2021 Jan;
93(4):2135-2143.
PMID: 33416303
Lipids, such for example the multifaceted category of glycerophospholipids (GP), play a major role in many biological processes. High-resolution mass spectrometry is able to identify these highly diverse lipid species...
5.
Helmer P, Nicolai M, Schwantes V, Bornhorst J, Hayen H
Free Radic Biol Med
. 2020 Oct;
162:216-224.
PMID: 33127566
The investigation of neurodegenerative and age-related diseases is a highly relevant topic in current research. Especially oxidative stress is thought to be the common underlying mechanism in diseases such as...
6.
Helmer P, Behrens A, Rudt E, Karst U, Hayen H
Anal Chem
. 2020 Sep;
92(17):12010-12016.
PMID: 32867498
In recent years, cardiolipin (CL) oxidation products were recognized as potential markers for mitochondrial dysfunction in conjunction with age related diseases. The analysis of oxidized CL requires powerful analysis techniques...
7.
Froning M, Helmer P, Hayen H
Rapid Commun Mass Spectrom
. 2020 Jul;
34(21):e8897.
PMID: 32673427
Rationale: Lipid A is a part of the lipopolysaccharide layer, which is a main component of the outer membrane from Gram-negative bacteria. It can be sensed by mammalians to identify...
8.
Helmer P, Wienken C, Korf A, Hayen H
J Chromatogr A
. 2020 Feb;
1619:460918.
PMID: 32008819
The anionic phospholipid class of cardiolipins (CL) is increasingly attracting scientific attention in the recent years. CL can be found as a functional component of mitochondrial membranes in almost all...
9.
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
Palomo-Guerrero M, Fado R, Casas M, Perez-Montero M, Baena M, Helmer P, et al.
Elife
. 2019 Dec;
8.
PMID: 31868590
Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty...
10.
Helmer P, Korf A, Hayen H
Rapid Commun Mass Spectrom
. 2019 Aug;
34(1):e8566.
PMID: 31469924
Rationale: Cardiolipins (CL) are a special lipid class which plays a main role in energy metabolism in mitochondria and is involved in apoptosis. In contrast to other glycerophospholipids, they contain...