Patrick Neuhofer
Overview
Explore the profile of Patrick Neuhofer including associated specialties, affiliations and a list of published articles.
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12
Citations
792
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Recent Articles
1.
Hasegawa K, Zhao Y, Garbuzov A, Corces M, Neuhofer P, Gillespie V, et al.
Nature
. 2024 Jul;
632(8023):201-208.
PMID: 39020172
Telomerase is intimately associated with stem cells and cancer, because it catalytically elongates telomeres-nucleoprotein caps that protect chromosome ends. Overexpression of telomerase reverse transcriptase (TERT) enhances the proliferation of cells...
2.
Guan L, Viswanathan V, Jiang Y, Vijayakumar S, Cao H, Zhao J, et al.
Genes Dev
. 2024 Jul;
38(11-12):569-582.
PMID: 38997156
Salivary gland homeostasis and regeneration after radiotherapy depend significantly on progenitor cells. However, the lineage of submandibular gland (SMG) progenitor cells remains less defined compared with other normal organs. Here,...
3.
Miller C, Sagiv-Barfi I, Neuhofer P, Czerwinski D, Bertozzi C, Cochran J, et al.
J Immunol
. 2023 May;
211(2):295-305.
PMID: 37256255
Spontaneous tumors that arise in genetically engineered mice recapitulate the natural tumor microenvironment and tumor-immune coevolution observed in human cancers, providing a more physiologically relevant preclinical model relative to implanted...
4.
Jones R, Karkanias J, Krasnow M, Pisco A, Quake S, Salzman J, et al.
Science
. 2022 May;
376(6594):eabl4896.
PMID: 35549404
Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. We created a human reference atlas comprising...
5.
Miller C, Sagiv-Barfi I, Neuhofer P, Czerwinski D, Artandi S, Bertozzi C, et al.
Cell Chem Biol
. 2021 Nov;
29(3):451-462.e8.
PMID: 34774126
Promoting immune activation within the tumor microenvironment (TME) is a promising therapeutic strategy to reverse tumor immunosuppression and elicit anti-tumor immunity. To enable tumor-localized immunotherapy following intravenous administration, we chemically...
6.
Neuhofer P, Roake C, Kim S, Lu R, West R, Charville G, et al.
Nature
. 2021 Sep;
597(7878):715-719.
PMID: 34526722
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer deaths worldwide. Studies in human tissues and in mouse models have suggested that for many cancers, stem cells...
7.
Lin S, Nascimento E, Gajera C, Chen L, Neuhofer P, Garbuzov A, et al.
Nature
. 2018 Apr;
556(7700):244-248.
PMID: 29618815
Hepatocytes are replenished gradually during homeostasis and robustly after liver injury. In adults, new hepatocytes originate from the existing hepatocyte pool, but the cellular source of renewing hepatocytes remains unclear....
8.
Song L, Wormann S, Ai J, Neuhofer P, Lesina M, Diakopoulos K, et al.
Gastroenterology
. 2015 Nov;
150(2):499-512.e20.
PMID: 26526716
Background & Aims: Under conditions of inflammation in the absence of micro-organisms (sterile inflammation), necrotic cells release damage-associated molecular patterns that bind to Toll-like receptors on immune cells to activate...
9.
Lesina M, Wormann S, Neuhofer P, Song L, Algul H
Semin Immunol
. 2014 Feb;
26(1):80-7.
PMID: 24572992
Interleukin-6 is an important pro-inflammatory cytokine strongly linked to the most burdened exocrine pancreatic diseases including acute pancreatitis, chronic pancreatitis and pancreatic cancer. However, its role in all these diseases...
10.
Zhang H, Neuhofer P, Song L, Rabe B, Lesina M, Kurkowski M, et al.
J Clin Invest
. 2013 Feb;
123(3):1019-31.
PMID: 23426178
Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis, ALI is also a major complication in severe acute pancreatitis...