Patrick J Rudewicz
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Explore the profile of Patrick J Rudewicz including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
119
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0
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Recent Articles
1.
Thoma G, Duthaler R, Waelchli R, Hauchard A, Bruno S, Strittmatter-Keller U, et al.
J Med Chem
. 2023 Jan;
66(3):2161-2168.
PMID: 36657024
The JAK kinases JAK1, JAK2, JAK3, and TYK2 play key roles in cytokine signaling. Activation of the JAK/STAT pathways is linked to many diseases involving the immune system, including atopic...
2.
Zang R, Barth A, Wong H, Marik J, Shen J, Lade J, et al.
J Med Chem
. 2022 Jul;
65(13):8713-8734.
PMID: 35790118
The "free drug hypothesis" assumes that, in the absence of transporters, the steady state free plasma concentrations equal to that at the site of action that elicit pharmacologic effects. While...
3.
Pedro L, Rudewicz P
Anal Chem
. 2020 Dec;
92(24):16005-16015.
PMID: 33280372
The analysis of large numbers of cells from a population results in information that does not reflect differences in cell phenotypes. Individual variations in cellular drug uptake, metabolism, and response...
4.
Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, et al.
J Med Chem
. 2020 Jul;
63(19):10773-10781.
PMID: 32667203
Visceral leishmaniasis is responsible for up to 30,000 deaths every year. Current treatments have shortcomings that include toxicity and variable efficacy across endemic regions. Previously, we reported the discovery of...
5.
Karpov A, Nieto-Oberhuber C, Abrams T, Beng-Louka E, Blanco E, Chamoin S, et al.
ACS Med Chem Lett
. 2019 Dec;
10(12):1674-1679.
PMID: 31857845
Targeted antimitotic agents are a promising class of anticancer therapies. Herein, we describe the development of a potent and selective antimitotic Eg5 inhibitor based antibody-drug conjugate (ADC). Preliminary studies were...
6.
Pomerantz A, Sari-Sarraf F, Grove K, Pedro L, Rudewicz P, Fathman J, et al.
Expert Opin Drug Discov
. 2018 Dec;
14(2):115-125.
PMID: 30583700
Single-cell imaging-based assays are an area of active and growing investment in drug discovery and development. This approach offers researchers the capability to interrogate rare subpopulations of cells with minimal...
7.
Grove K, Hoque S, Rudewicz P
Rapid Commun Mass Spectrom
. 2018 Nov;
33(3):252-258.
PMID: 30394607
Rationale: High mass and high spatial resolution matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) opens new possibilities for the detailed study of the hepatic metabolism of drugs. The spatial...
8.
Grove K, Kansara V, Prentiss M, Long D, Mogi M, Kim S, et al.
SLAS Discov
. 2017 Aug;
22(10):1239-1245.
PMID: 28787579
Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) is becoming an important technology to determine the distribution of drugs and their metabolites in the tissue of preclinical species after dosing....
9.
Yue Q, Mulder T, Rudewicz P, Solon E, Budha N, Ware J, et al.
Drug Metab Dispos
. 2012 Dec;
41(2):508-17.
PMID: 23223496
The compound (S)-1-[(S)-2-cyclohexyl-2-([S]-2-[methylamino]propanamido)acetyl]-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide (GDC-0152) is a peptidomimetic small molecule antagonist of inhibitor of apoptosis (IAP) proteins with antitumor activity. The mass balance, pharmacokinetics, tissue distribution and metabolism of GDC-0152 was...
10.
Shahidi-Latham S, Dutta S, Prieto Conaway M, Rudewicz P
Anal Chem
. 2012 Jul;
84(16):7158-65.
PMID: 22827834
In drug discovery and development, in vitro absorption and metabolism assays along with in vivo pharmacokinetic (PK), pharmacodynamic (PD), and toxicokinetic (TK) studies are used to evaluate a potential drug...