Patrick Hess
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Explore the profile of Patrick Hess including associated specialties, affiliations and a list of published articles.
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43
Citations
963
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Recent Articles
31.
Remen L, Bezencon O, Richard-Bildstein S, Bur D, Prade L, Corminboeuf O, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(23):6762-5.
PMID: 19853442
New classes of de novo designed renin inhibitors are reported. Some of these compounds display excellent in vitro and in vivo activities toward human renin in a TGR model. The...
32.
Bezencon O, Bur D, Weller T, Richard-Bildstein S, Remen L, Sifferlen T, et al.
J Med Chem
. 2009 Apr;
52(12):3689-702.
PMID: 19358611
Starting from known piperidine renin inhibitors, a new series of 3,9-diazabicyclo[3.3.1]nonene derivatives was rationally designed and prepared. Optimization of the positions 3, 6, and 7 of the diazabicyclonene template led...
33.
Iglarz M, Binkert C, Morrison K, Fischli W, Gatfield J, Treiber A, et al.
J Pharmacol Exp Ther
. 2008 Sep;
327(3):736-45.
PMID: 18780830
Macitentan, also called Actelion-1 or ACT-064992 [N-[5-(4-bromophenyl)-6-(2-(5-bromopyrimidin-2-yloxy)ethoxy)-pyrimidin-4-yl]-N'-propylaminosulfonamide], is a new dual ET(A)/ET(B) endothelin (ET) receptor antagonist designed for tissue targeting. Selection of macitentan was based on inhibitory potency on both...
34.
Brisbare-Roch C, Dingemanse J, Koberstein R, Hoever P, Aissaoui H, Flores S, et al.
Nat Med
. 2007 Jan;
13(2):150-5.
PMID: 17259994
Orexins are hypothalamic peptides that play an important role in maintaining wakefulness in mammals. Permanent deficit in orexinergic function is a pathophysiological hallmark of rodent, canine and human narcolepsy. Here...
35.
Clozel M, Hess P, Rey M, Iglarz M, Binkert C, Qiu C
Exp Biol Med (Maywood)
. 2006 Jun;
231(6):967-73.
PMID: 16741032
The dual endothelin receptor antagonist, bosentan, and the phosphodiesterase inhibitor, sildenafil, are efficacious in experimental and clinical pulmonary hypertension (PHT). The effects of bosentan, sildenafil, and their combination were evaluated...
36.
Clozel M, Hess P, Qiu C, Ding S, Rey M
J Pharmacol Exp Ther
. 2005 Nov;
316(3):1115-21.
PMID: 16267137
Urotensin-II (U-II) is a cyclic peptide that acts through a specific G-protein-coupled receptor, UT receptor. Urotensin-II and UT receptors have been described in pancreas and kidney, but their function is...
37.
Clozel M, Binkert C, Birker-Robaczewska M, Boukhadra C, Ding S, Fischli W, et al.
J Pharmacol Exp Ther
. 2004 May;
311(1):204-12.
PMID: 15146030
Urotensin-II (U-II) is a cyclic peptide now described as the most potent vasoconstrictor known. U-II binds to a specific G protein-coupled receptor, formerly the orphan receptor GPR14, now renamed urotensin...
38.
Bolli M, Marfurt J, Grisostomi C, Boss C, Binkert C, Hess P, et al.
J Med Chem
. 2004 May;
47(11):2776-95.
PMID: 15139756
Since its discovery in 1988 by Yanagisawa et al., endothelin (ET), a potent vasoconstrictor, has been widely implicated in the pathophysiology of cardiovascular, cerebrovascular, and renal diseases. Many research groups...
39.
Ding S, Qiu C, Hess P, Xi J, Zheng N, Clozel M
J Cardiovasc Pharmacol
. 2003 Jun;
42(1):48-54.
PMID: 12827026
Diabetic nephropathy is associated with enhanced renal synthesis of endothelin (ET)-1. The goal of this study was to investigate the effects of dual ET receptor antagonism in the early phase...
40.
Bolli M, Boss C, Clozel M, Fischli W, Hess P, Weller T
Bioorg Med Chem Lett
. 2003 Mar;
13(5):955-9.
PMID: 12617929
A series of compounds structurally related to bosentan 1 featuring an unsaturated side chain at position 6 of the core pyrimidine have been studied for their potential to block the...