Walter Fischli
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Explore the profile of Walter Fischli including associated specialties, affiliations and a list of published articles.
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19
Citations
501
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Recent Articles
1.
Le Bihan A, de Kanter R, Angulo-Barturen I, Binkert C, Boss C, Brun R, et al.
PLoS Med
. 2016 Oct;
13(10):e1002138.
PMID: 27701420
Background: Artemisinin resistance observed in Southeast Asia threatens the continued use of artemisinin-based combination therapy in endemic countries. Additionally, the diversity of chemical mode of action in the global portfolio...
2.
Boss C, Aissaoui H, Amaral N, Bauer A, Bazire S, Binkert C, et al.
ChemMedChem
. 2016 Jul;
11(18):1995-2014.
PMID: 27471138
More than 40 % of the world's population is at risk of being infected with malaria. Most malaria cases occur in the countries of sub-Saharan Africa, Central and South America,...
3.
Kosanovic D, Luitel H, Dahal B, Cornitescu T, Janssen W, Danser A, et al.
Eur Respir J
. 2015 Jun;
46(4):1084-94.
PMID: 26113671
Limited literature sources implicate mast-cell mediator chymase in the pathologies of pulmonary hypertension and pulmonary fibrosis. However, there is no evidence on the contribution of chymase to the development of...
4.
Bolli M, Boss C, Binkert C, Buchmann S, Bur D, Hess P, et al.
J Med Chem
. 2012 Aug;
55(17):7849-61.
PMID: 22862294
Starting from the structure of bosentan (1), we embarked on a medicinal chemistry program aiming at the identification of novel potent dual endothelin receptor antagonists with high oral efficacy. This...
5.
St-Jacques R, Toulmond S, Auger A, Binkert C, Cromlish W, Fischli W, et al.
J Renin Angiotensin Aldosterone Syst
. 2011 Mar;
12(3):133-45.
PMID: 21393355
Introduction: The hypertensive double-transgenic (dTG) rat strain, expressing human renin and angiotensinogen, develops severe hypertension and organ damage and 50% of individuals die by 7 weeks of age. Here, we...
6.
Bauer Y, Hess P, Qiu C, Klenk A, Renault B, Wanner D, et al.
Hypertension
. 2011 Mar;
57(4):795-801.
PMID: 21357272
The renin-angiotensin system is a well-known regulator of blood pressure and plays an important role in the pathogenesis of cardiovascular disease and renal damage. Genetic factors, including single nucleotide polymorphisms...
7.
Corminboeuf O, Bezencon O, Remen L, Grisostomi C, Richard-Bildstein S, Bur D, et al.
Bioorg Med Chem Lett
. 2010 Sep;
20(21):6291-6.
PMID: 20843690
The optimization of the 4-position of recently described new 3,4-disubstituted piperidine-based renin inhibitors is reported herein. The synthesis and characterization of compounds leading to the discovery of 11 (ACT-178882, MK-1597),...
8.
Corminboeuf O, Bezencon O, Grisostomi C, Remen L, Richard-Bildstein S, Bur D, et al.
Bioorg Med Chem Lett
. 2010 Sep;
20(21):6286-90.
PMID: 20843686
The discovery of a new series of piperidine-based renin inhibitors is described herein. SAR optimization upon the P3 renin sub-pocket is described, leading to the discovery of 9 and 41,...
9.
Remen L, Bezencon O, Richard-Bildstein S, Bur D, Prade L, Corminboeuf O, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(23):6762-5.
PMID: 19853442
New classes of de novo designed renin inhibitors are reported. Some of these compounds display excellent in vitro and in vivo activities toward human renin in a TGR model. The...
10.
Bezencon O, Bur D, Weller T, Richard-Bildstein S, Remen L, Sifferlen T, et al.
J Med Chem
. 2009 Apr;
52(12):3689-702.
PMID: 19358611
Starting from known piperidine renin inhibitors, a new series of 3,9-diazabicyclo[3.3.1]nonene derivatives was rationally designed and prepared. Optimization of the positions 3, 6, and 7 of the diazabicyclonene template led...