Patrick C Fraering
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Explore the profile of Patrick C Fraering including associated specialties, affiliations and a list of published articles.
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42
Citations
1149
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Recent Articles
1.
Teng Z, Kartalou G, Dagar S, Fraering P, Lessmann V, Gottmann K
Cell Death Discov
. 2023 Dec;
9(1):444.
PMID: 38062019
Synaptotoxic Aβ oligomers are thought to play a major role in the early pathology of Alzheimer´s disease (AD). However, the molecular mechanisms involved in Aβ-induced synaptic dysfunction and synapse damage...
2.
Mosser S, Gerber H, Fraering P
J Neurochem
. 2020 Aug;
156(6):943-956.
PMID: 32757390
Recent evidence supports the emerging hypothesis that the amyloid-β precursor protein C-terminal fragments (APP-CTFs) and dysregulations in both their qualitative and quantitative productions may actively and directly contribute to the...
3.
Gerber H, Mosser S, Boury-Jamot B, Stumpe M, Piersigilli A, Goepfert C, et al.
Acta Neuropathol Commun
. 2019 Feb;
7(1):13.
PMID: 30704515
The adipocyte plasma membrane-associated protein APMAP is expressed in the brain where it associates with γ-secretase, a protease responsible for the generation of the amyloid-β peptides (Aβ) implicated in the...
4.
Walter S, Jumpertz T, Huttenrauch M, Ogorek I, Gerber H, Storck S, et al.
Acta Neuropathol
. 2018 Nov;
137(2):239-257.
PMID: 30426203
Brain accumulation and aggregation of amyloid-β (Aβ) peptides is a critical step in the pathogenesis of Alzheimer's disease (AD). Full-length Aβ peptides (mainly Aβ1-40 and Aβ1-42) are produced through sequential...
5.
Cam M, Durieu E, Bodin M, Manousopoulou A, Koslowski S, Vasylieva N, et al.
J Alzheimers Dis
. 2018 Mar;
62(4):1663-1681.
PMID: 29504531
Generation of amyloid-β peptides (Aβs) by proteolytic cleavage of the amyloid-β protein precursor (AβPP), especially increased production of Aβ42/Aβ43 over Aβ40, and their aggregation as oligomers and plaques, represent a...
6.
The Alzheimer's Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides
Siegel G, Gerber H, Koch P, Bruestle O, Fraering P, Rajendran L
Cell Rep
. 2017 Jun;
19(10):1967-1976.
PMID: 28591569
Alzheimer's disease is characterized by intracerebral deposition of β-amyloid (Aβ). While Aβ is the most abundant form, neurotoxicity is mainly mediated by Aβ. Sequential cleavage of amyloid precursor protein (APP)...
7.
Gerber H, Wu F, Dimitrov M, Garcia Osuna G, Fraering P
J Biol Chem
. 2017 Jan;
292(9):3751-3767.
PMID: 28096459
Recent evidence suggests involvement of biometal homeostasis in the pathological mechanisms in Alzheimer's disease (AD). For example, increased intracellular copper or zinc has been linked to a reduction in secreted...
8.
Lu Y, Wan J, Yang Z, Lei X, Niu Q, Jiang L, et al.
FASEB J
. 2016 Dec;
31(4):1382-1397.
PMID: 28034848
Deregulation of the TAM (TYRO3, AXL, and MERTK) family of receptor tyrosine kinases (RTKs) has recently been demonstrated to predominately promote survival and chemoresistance of cancer cells. Intramembrane proteolysis mediated...
9.
Borcel E, Palczynska M, Krzisch M, Dimitrov M, Ulrich G, Toni N, et al.
Sci Rep
. 2016 Dec;
6:39310.
PMID: 27991559
Neurexins are transmembrane synaptic cell adhesion molecules involved in the development and maturation of neuronal synapses. In the present study, we report that Nrxn3β is processed by the metalloproteases ADAM10,...
10.
Ayciriex S, Gerber H, Garcia Osuna G, Chami M, Stahlberg H, Shevchenko A, et al.
Biochem J
. 2016 Jan;
473(3):321-34.
PMID: 26811537
γ-Secretase is a multi-subunit membrane protease complex that catalyses the final intramembrane cleavage of the β-amyloid precursor protein (APP) during the neuronal production of amyloid-β peptides (Aβ), which are implicated...