Patrick C Fraering
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Explore the profile of Patrick C Fraering including associated specialties, affiliations and a list of published articles.
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42
Citations
1149
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Recent Articles
11.
Lei X, Yu J, Niu Q, Liu J, Fraering P, Wu F
Sci Rep
. 2015 Nov;
5:16541.
PMID: 26567970
Known γ-secretase inhibitors or modulators display an undesirable pharmacokinetic profile and toxicity and have therefore not been successful in clinical trials for Alzheimer's disease (AD). So far, no compounds from...
12.
Lopez A, Dimitrov M, Gerber H, Braman V, Hacker D, Wurm F, et al.
Biotechnol Bioeng
. 2015 Jun;
112(12):2516-26.
PMID: 26059427
Alzheimer's disease (AD)-associated γ-secretase is a ubiquitously expressed multi-subunit protease complex embedded in the lipid bilayer of cellular compartments including endosomes and the plasma membrane. Although γ-secretase is of crucial...
13.
Beduer A, Joris P, Mosser S, Fraering P, Renaud P
J Neural Eng
. 2015 Feb;
12(2):024001.
PMID: 25686025
Objective: Alzheimer disease (AD) is the most common form of neurodegenerative disease in elderly people. Toxic brain amyloid-beta (Aß) aggregates and ensuing cell death are believed to play a central...
14.
Matz A, Halamoda-Kenzaoui B, Hamelin R, Mosser S, Alattia J, Dimitrov M, et al.
J Neurochem
. 2014 Dec;
133(3):409-21.
PMID: 25458374
An important pathological hallmark of Alzheimer's disease (AD) is the deposition of amyloid-beta (Aβ) peptides in the brain parenchyma, leading to neuronal death and impaired learning and memory. The protease...
15.
Barone E, Mosser S, Fraering P
Biochim Biophys Acta
. 2014 Oct;
1842(12 Pt A):2500-9.
PMID: 25315299
Rapid remodeling of the actin cytoskeleton in the pre- and/or post-synaptic compartments is responsible for the regulation of neuronal plasticity,which is an important process for learning and memory. Cofilin1 plays...
16.
Mosser S, Alattia J, Dimitrov M, Matz A, Pascual J, Schneider B, et al.
Hum Mol Genet
. 2014 Sep;
24(2):371-82.
PMID: 25180020
The deposition of amyloid-beta (Aβ) aggregates in the brain is a major pathological hallmark of Alzheimer's disease (AD). Aβ is generated from the cleavage of C-terminal fragments of the amyloid...
17.
Beduer A, Braschler T, Peric O, Fantner G, Mosser S, Fraering P, et al.
Adv Healthc Mater
. 2014 Sep;
4(2):301-12.
PMID: 25178838
Millimeter to centimeter-sized injectable neural scaffolds based on macroporous cryogels are presented. The polymer-scaffolds are made from alginate and carboxymethyl-cellulose by a novel simple one-pot cryosynthesis. They allow surgical sterility...
18.
Eleuteri S, Di Giovanni S, Rockenstein E, Mante M, Adame A, Trejo M, et al.
Neurobiol Dis
. 2014 Sep;
74:144-57.
PMID: 25173807
Aβ accumulation plays a central role in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that the process of Aβ nucleated polymerization is essential for Aβ fibril formation, pathology...
19.
Beduer A, Joris P, Mosser S, Delattre V, Fraering P, Renaud P
Biosens Bioelectron
. 2014 May;
60:143-53.
PMID: 24794406
Electrical impedance spectroscopy measurements were performed in post-mortem mice brains using a flexible probe with an embedded micrometric electrode array. Combined with a peak resistance frequency method this allowed obtaining...
20.
Schweizer C, Fraering P, Kuhn L
Neurochem Int
. 2014 Mar;
71:17-21.
PMID: 24662374
Ferritin H, the major iron storage protein, has essential functions in early embryonic development as well as in adult liver and intestine. To address the question whether ferritin H has...