Patrick Bertolino
Overview
Explore the profile of Patrick Bertolino including associated specialties, affiliations and a list of published articles.
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75
Citations
2411
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Recent Articles
1.
English K, Kwan R, Holz L, McGuffog C, Krol J, Kempe D, et al.
Nat Commun
. 2024 Feb;
15(1):1261.
PMID: 38341416
While CD4 T cells are a prerequisite for CD8 T cell-mediated protection against intracellular hepatotropic pathogens, the mechanisms facilitating the transfer of CD4-help to intrahepatic CD8 T cells are unknown....
2.
Adams R, Carter-Cusack D, Llanes G, Hunter C, Vinnakota J, Ruitenberg M, et al.
Blood
. 2023 Dec;
143(10):912-929.
PMID: 38048572
Chronic graft-versus-host disease (cGVHD) remains a significant complication of allogeneic hematopoietic stem cell transplantation. Central nervous system (CNS) involvement is becoming increasingly recognized, in which brain-infiltrating donor major histocompatibility complex...
3.
Ganley M, Holz L, Minnell J, de Menezes M, Burn O, Chan Yew Poa K, et al.
Nat Immunol
. 2023 Jul;
24(9):1487-1498.
PMID: 37474653
Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive replication occurs, emerging later as merozoites that...
4.
Grootveld A, Kyaw W, Panova V, Lau A, Ashwin E, Seuzaret G, et al.
Cell
. 2023 Mar;
186(6):1144-1161.e18.
PMID: 36868219
Germinal centers (GCs) that form within lymphoid follicles during antibody responses are sites of massive cell death. Tingible body macrophages (TBMs) are tasked with apoptotic cell clearance to prevent secondary...
5.
Chen J, Zhao Y, Zhang F, Li J, Boland J, Cheng N, et al.
Cell Mol Life Sci
. 2022 Jul;
79(8):443.
PMID: 35867177
MiR-181 expression levels increased in hepatocellular carcinoma (HCC) compared to non-cancerous tissues. MiR-181 has been widely reported as a possible driver of tumourigenesis but also acts as a tumour suppressor....
6.
English K, Tan S, Kwan R, Holz L, Sierro F, McGuffog C, et al.
Immunol Cell Biol
. 2022 Jun;
100(6):394-408.
PMID: 35718354
Portal tracts are key intrahepatic structures where leukocytes accumulate during immune responses. They contain the blood inflow, which includes portal blood from the gut, and lymphatic and biliary outflow of...
7.
Nalkurthi C, Schroder W, Melino M, Irvine K, Nyuydzefe M, Chen W, et al.
JHEP Rep
. 2021 Dec;
4(1):100386.
PMID: 34917911
Background & Aims: Fibrosis, the primary cause of morbidity in chronic liver disease, is induced by pro-inflammatory cytokines, immune cell infiltrates, and tissue resident cells that drive excessive myofibroblast activation,...
8.
Son E, Faridi P, Paul-Heng M, Leong M, English K, Ramarathinam S, et al.
J Clin Invest
. 2021 Aug;
131(21).
PMID: 34428180
While direct allorecognition underpins both solid organ allograft rejection and tolerance induction, the specific molecular targets of most directly alloreactive CD8+ T cells have not been defined. In this study,...
9.
English K, Bowen D, Bertolino P
Immunol Cell Biol
. 2021 Jun;
99(6):565-569.
PMID: 34080232
No abstract available.
10.
Bhattacharyya N, Counoupas C, Daniel L, Zhang G, Cook S, Cootes T, et al.
J Immunol
. 2021 May;
206(12):2875-2887.
PMID: 34049970
The quality of T cell responses depends on the lymphocytes' ability to undergo clonal expansion, acquire effector functions, and traffic to the site of infection. Although TCR signal strength is...