Patrick Beaudette
Overview
Explore the profile of Patrick Beaudette including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
247
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0
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Recent Articles
1.
Mikuda N, Kolesnichenko M, Beaudette P, Popp O, Uyar B, Sun W, et al.
EMBO J
. 2018 Nov;
37(24).
PMID: 30467221
The IκB kinase (IKK) is considered to control gene expression primarily through activation of the transcription factor NF-κB. However, we show here that IKK additionally regulates gene expression on post-transcriptional...
2.
Eccles R, Czajkowski M, Barth C, Muller P, McShane E, Grunwald S, et al.
Nat Commun
. 2016 Oct;
7:12963.
PMID: 27713425
Protein kinase A is a key mediator of cAMP signalling downstream of G-protein-coupled receptors, a signalling pathway conserved in all eukaryotes. cAMP binding to the regulatory subunits (PKAR) relieves their...
3.
Beaudette P, Popp O, Dittmar G
Proteomics
. 2015 Oct;
16(2):273-87.
PMID: 26460060
Protein ubiquitination is a powerful modulator of cellular functions. Classically linked to the degradation of proteins, it also plays a role in intracellular localization, DNA damage response, vesicle fusion events,...
4.
Jerke U, Perez Hernandez D, Beaudette P, Korkmaz B, Dittmar G, Kettritz R
Kidney Int
. 2015 Jun;
88(4):764-75.
PMID: 26061547
Neutrophil serine proteases (NSPs) are released from activated neutrophils during inflammation. Here we studied the transfer of the three major NSPs, namely proteinase 3, human neutrophil elastase, and cathepsin G,...
5.
Yilmaz Z, Kofahl B, Beaudette P, Baum K, Ipenberg I, Weih F, et al.
Cell Rep
. 2014 Dec;
9(5):1756-1769.
PMID: 25482563
The mechanisms that govern proteolytic maturation or complete destruction of the precursor proteins p100 and p105 are fundamental to homeostasis and activation of NF-κB; however, they remain poorly understood. Using...
6.
Muller-Rischart A, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, et al.
Mol Cell
. 2013 Mar;
49(5):908-21.
PMID: 23453807
Parkin, a RING-between-RING-type E3 ubiquitin ligase associated with Parkinson's disease, has a wide neuroprotective activity, preventing cell death in various stress paradigms. We identified a stress-protective pathway regulated by parkin...
7.
Beaudette P, Rossi N, Huesgen P, Yu X, Shenoi R, Doucet A, et al.
Anal Chem
. 2011 Jul;
83(17):6500-10.
PMID: 21774540
High molecular weight hyperbranched polyglycerol (HPG) was selected for development as a soluble polymer support for the targeted selection and release of primary-amine containing peptides from a complex mixture. HPG...
8.
Beaudette P, Bateman K
J Chromatogr B Analyt Technol Biomed Life Sci
. 2004 Jul;
809(1):153-8.
PMID: 15282106
Early in the discovery stage, the measurement of drug candidates in biological fluids as a function time provides important information used in decision making for lead optimization. The detection methodology...