Patricia S Estes
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Explore the profile of Patricia S Estes including associated specialties, affiliations and a list of published articles.
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9
Citations
587
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Recent Articles
1.
Daniel S, Russ A, Guthridge K, Raina A, Estes P, Parsons L, et al.
Biol Open
. 2018 Jan;
7(1).
PMID: 29361610
() encodes a conserved tumor suppressor with established roles in cell polarity, asymmetric division, and proliferation control. Lgl's human orthologs, HUGL1 and HUGL2, are altered in human cancers, however, its...
2.
Coyne A, Yamada S, Siddegowda B, Estes P, Zaepfel B, Johannesmeyer J, et al.
Hum Mol Genet
. 2015 Sep;
24(24):6886-98.
PMID: 26385636
RNA dysregulation is a newly recognized disease mechanism in amyotrophic lateral sclerosis (ALS). Here we identify Drosophila fragile X mental retardation protein (dFMRP) as a robust genetic modifier of TDP-43-dependent...
3.
Joardar A, Menzl J, Podolsky T, Manzo E, Estes P, Ashford S, et al.
Hum Mol Genet
. 2014 Nov;
24(6):1741-54.
PMID: 25432537
Amyotrophic Lateral Sclerosis (ALS) is a progressive neuromuscular disease for which there is no cure. We have previously developed a Drosophila model of ALS based on TDP-43 that recapitulates several...
4.
Coyne A, Siddegowda B, Estes P, Johannesmeyer J, Kovalik T, Daniel S, et al.
J Neurosci
. 2014 Nov;
34(48):15962-74.
PMID: 25429138
TDP-43 is an RNA-binding protein linked to amyotrophic lateral sclerosis (ALS) that is known to regulate the splicing, transport, and storage of specific mRNAs into stress granules. Although TDP-43 has...
5.
Estes P, Daniel S, McCallum A, Boehringer A, Sukhina A, Zwick R, et al.
Dis Model Mech
. 2013 Mar;
6(3):721-33.
PMID: 23471911
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by complex neuronal and glial phenotypes. Recently, RNA-based mechanisms have been linked to ALS via RNA-binding proteins such as TDP-43, which...
6.
Estes P, Boehringer A, Zwick R, Tang J, Grigsby B, Zarnescu D
Hum Mol Genet
. 2011 Mar;
20(12):2308-21.
PMID: 21441568
The RNA-binding protein TDP-43 has been linked to amyotrophic lateral sclerosis (ALS) both as a causative locus and as a marker of pathology. With several missense mutations being identified within...
7.
Estes P, OShea M, Clasen S, Zarnescu D
Mol Cell Neurosci
. 2008 Jul;
39(2):170-9.
PMID: 18655836
Fragile X syndrome, the most common form of inherited mental retardation is caused by mutations in the FMR1 gene. FMR1 encodes an RNA-binding protein thought to control the transport and...
8.
Barbee S, Estes P, Cziko A, Hillebrand J, Luedeman R, Coller J, et al.
Neuron
. 2006 Dec;
52(6):997-1009.
PMID: 17178403
Local control of mRNA translation modulates neuronal development, synaptic plasticity, and memory formation. A poorly understood aspect of this control is the role and composition of ribonucleoprotein (RNP) particles that...
9.
Estes P, Jackson T, Stimson D, Sanyal S, Kelly L, Ramaswami M
Genetics
. 2003 Sep;
165(1):185-96.
PMID: 14504226
The dicistronic Drosophila stoned mRNA produces two proteins, stonedA and stonedB, that are localized at nerve terminals. While the stoned locus is required for synaptic-vesicle cycling in neurons, distinct or...