Patricia Rockwell
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Explore the profile of Patricia Rockwell including associated specialties, affiliations and a list of published articles.
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24
Citations
308
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Recent Articles
1.
Ndukwe K, Serrano P, Rockwell P, Xie L, Figueiredo-Pereira M
J Alzheimers Dis
. 2025 Feb;
104(1):173-190.
PMID: 39924842
BackgroundNearly two-thirds of Alzheimer's disease (AD) patients are women. Therapeutics for women are critical to lowering their elevated risk of developing this major cause of adult dementia. Moreover, targeting epigenetic...
2.
Birnbaum E, Xie L, Serrano P, Rockwell P, Figueiredo-Pereira M
bioRxiv
. 2024 Nov;
PMID: 39553925
Neuroinflammation is a key pathological hallmark of Alzheimer's disease (AD). Investigational and FDA approved drugs targeting inflammation already exist, thus drug repurposing for AD is a suitable approach. BT-11 is...
3.
Wallace C, Oliveros G, Xie L, Serrano P, Rockwell P, Figueiredo-Pereira M
Sci Rep
. 2024 Feb;
14(1):3730.
PMID: 38355687
Alzheimer's disease (AD) is the major form of dementia prevalent in older adults and with a high incidence in females. Identification of early biomarkers is essential for preventive intervention to...
4.
Ndukwe K, Serrano P, Rockwell P, Xie L, Figueiredo-Pereira M
bioRxiv
. 2024 Jan;
PMID: 38234827
Nearly two-thirds of patients with Alzheimer's are women. Identifying therapeutics specific for women is critical to lowering their elevated risk for developing this major cause of adult dementia. Moreover, targeting...
5.
Chaudry O, Ndukwe K, Xie L, Figueiredo-Pereira M, Serrano P, Rockwell P
Sci Rep
. 2022 Nov;
12(1):19129.
PMID: 36352024
Alzheimer's disease (AD) is a progressive neurodegenerative disease that is most prevalent in females. While estrogen provides neuroprotection in females, sex mediated differences in the development of AD pathology are...
6.
Wallace C, Oliveros G, Serrano P, Rockwell P, Xie L, Figueiredo-Pereira M
Life Sci Alliance
. 2022 Sep;
5(12).
PMID: 36167438
We investigated the relevance of the prostaglandin D2 pathway in Alzheimer's disease, because prostaglandin D2 is a major prostaglandin in the brain. Thus, its contribution to Alzheimer's disease merits attention,...
7.
Oliveros G, Wallace C, Chaudry O, Liu Q, Qiu Y, Xie L, et al.
Brain
. 2022 Apr;
146(3):898-911.
PMID: 35411386
Alzheimer's disease is a multifactorial disease that exhibits cognitive deficits, neuronal loss, amyloid plaques, neurofibrillary tangles and neuroinflammation in the brain. Hence, a multi-target drug would improve treatment efficacy. We...
8.
Avila J, Kiprowska M, Jean-Louis T, Rockwell P, Figueiredo-Pereira M, Serrano P
Brain Behav
. 2019 Nov;
10(1):e01465.
PMID: 31769222
Background: Inflammation in the brain is mediated by the cyclooxygenase pathway, which leads to the production of prostaglandins. Prostaglandin (PG) D2, the most abundant PG in the brain, increases under...
9.
Wang H, Cheung F, Stoll A, Rockwell P, Figueiredo-Pereira M
Biochim Biophys Acta Mol Basis Dis
. 2019 Feb;
1865(6):1436-1450.
PMID: 30796971
Mitochondrial impairment and calcium (Ca) dyshomeostasis are associated with Parkinson's disease (PD). When intracellular ATP levels are lowered, Ca-ATPase pumps are impaired causing cytoplasmic Ca to be elevated and calpain...
10.
Jean-Louis T, Rockwell P, Figueiredo-Pereira M
Neurobiol Aging
. 2017 Nov;
62:130-145.
PMID: 29149631
Regulation of the amyloid precursor protein (APP) processing by α- and β-secretases is of special interest to Alzheimer's disease (AD), as these proteases prevent or mediate amyloid beta formation, respectively....