Pasi K Korhonen
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Explore the profile of Pasi K Korhonen including associated specialties, affiliations and a list of published articles.
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95
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1436
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Recent Articles
1.
Campos T, Korhonen P, Young N, Chang B, Gasser R
Comput Struct Biotechnol J
. 2024 Aug;
23:3081-3089.
PMID: 39185442
Detailed explorations of the model organisms (elegant worm) and (vinegar fly) have substantially improved our knowledge and understanding of biological processes and pathways in metazoan organisms. Extensive functional genomic and...
2.
Zheng Y, Young N, Campos T, Korhonen P, Wang T, Sumanam S, et al.
Int J Parasitol
. 2024 Aug;
54(13):705-715.
PMID: 39168434
Millions of livestock animals worldwide are infected with the haematophagous barber's pole worm, Haemonchus contortus, the aetiological agent of haemonchosis. Despite the major significance of this parasite worldwide and its...
3.
Korhonen P, La Rosa G, Sumanam S, Gomez Morales M, Ludovisi A, Pozio E, et al.
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 39000473
Nematodes of the genus are important pathogens of humans and animals. This study aimed to enhance the genomic and transcriptomic resources for (non-encapsulated phenotype) and (encapsulated phenotype) and to explore...
4.
Campos T, Korhonen P, Young N, Wang T, Song J, Marhoefer R, et al.
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 39000124
Over the years, comprehensive explorations of the model organisms (elegant worm) and (vinegar fly) have contributed substantially to our understanding of complex biological processes and pathways in multicellular organisms generally....
5.
Korhonen P, Wang T, Young N, Byrne J, Campos T, Chang B, et al.
Comput Struct Biotechnol J
. 2024 Mar;
23:1026-1035.
PMID: 38435301
Advances in single cell technologies are allowing investigations of a wide range of biological processes and pathways in animals, such as the multicellular model organism - a free-living nematode. However,...
6.
Shanley H, Taki A, Nguyen N, Wang T, Byrne J, Ang C, et al.
Int J Parasitol Drugs Drug Resist
. 2024 Jan;
24:100522.
PMID: 38295619
Within the context of our anthelmintic discovery program, we recently identified and evaluated a quinoline derivative, called ABX464 or obefazimod, as a nematocidal candidate; synthesised a series of analogues which...
7.
Ma J, Song J, Young N, Chang B, Korhonen P, Campos T, et al.
Brief Bioinform
. 2023 Dec;
25(1).
PMID: 38152979
The identification and characterization of essential genes are central to our understanding of the core biological functions in eukaryotic organisms, and has important implications for the treatment of diseases caused...
8.
Structure activity relationship and target prediction for ABX464 analogues in Caenorhabditis elegans
Shanley H, Taki A, Nguyen N, Wang T, Byrne J, Ang C, et al.
Bioorg Med Chem
. 2023 Dec;
98:117540.
PMID: 38134663
Global challenges with treatment failures and/or widespread resistance in parasitic worms against commercially available anthelmintics lend impetus to the development of new anthelmintics with novel mechanism(s) of action. The free-living...
9.
Wang T, Koukoulis T, Vella L, Su H, Purnianto A, Nie S, et al.
Int J Mol Sci
. 2023 Jul;
24(13).
PMID: 37446130
Many parasitic worms have a major adverse impact on human and animal populations worldwide due to the chronicity of their infections. There is a growing body of evidence indicating that...
10.
Kinkar L, Korhonen P, Saarma U, Wang T, Zhu X, Harliwong I, et al.
Mol Ecol Resour
. 2023 Feb;
23(4):833-843.
PMID: 36727564
Clonorchis sinensis is a carcinogenic liver fluke that causes clonorchiasis-a neglected tropical disease (NTD) affecting ~35 million people worldwide. No vaccine is available, and chemotherapy relies on one anthelmintic, praziquantel....