Pascale N Lacor
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Explore the profile of Pascale N Lacor including associated specialties, affiliations and a list of published articles.
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21
Citations
2849
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Recent Articles
1.
Taylor X, Noristani H, Fitzgerald G, Oluoch H, Babb N, McGathey T, et al.
Mol Neurodegener
. 2024 Oct;
19(1):77.
PMID: 39434125
Background: Anti-amyloid-β (Aβ) immunotherapy trials have revealed amyloid-related imaging abnormalities (ARIA) as the most prevalent and serious adverse events linked to pathological changes in cerebral vasculature. Recent studies underscore the...
2.
Xie Z, Shapiro L, Cahill M, Russell T, Lacor P, Klein W, et al.
Eur J Neurosci
. 2018 Dec;
49(9):1091-1101.
PMID: 30565792
Synapse degeneration and dendritic spine dysgenesis are believed to be crucial early steps in Alzheimer's disease (AD), and correlate with cognitive deficits in AD patients. Soluble amyloid beta (Aβ)-derived oligomers,...
3.
Sebollela A, Cline E, Popova I, Luo K, Sun X, Ahn J, et al.
J Neurochem
. 2017 Jul;
142(6):934-947.
PMID: 28670737
Brain accumulation of soluble oligomers of the amyloid-β peptide (AβOs) is increasingly considered a key early event in the pathogenesis of Alzheimer's disease (AD). A variety of AβO species have...
4.
Epelbaum S, Youssef I, Lacor P, Chaurand P, Duplus E, Brugg B, et al.
Neurobiol Aging
. 2015 Apr;
36(6):2043-52.
PMID: 25862419
Amyloid-β (Aβ) oligomers are the suspected culprit as initiators of Alzheimer's disease (AD). However, their diffusion in the brain remains unknown. Here, we studied Aβ oligomers' dissemination and evaluated their...
5.
Perez S, Raghanti M, Hof P, Kramer L, Ikonomovic M, Lacor P, et al.
J Comp Neurol
. 2013 Jul;
521(18):4318-38.
PMID: 23881733
The two major histopathologic hallmarks of Alzheimer's disease (AD) are amyloid beta protein (Aβ) plaques and neurofibrillary tangles (NFT). Aβ pathology is a common feature in the aged nonhuman primate...
6.
Disruption of neocortical histone H3 homeostasis by soluble Aβ: implications for Alzheimer's disease
Unger Lithner C, Lacor P, Zhao W, Mustafiz T, Klein W, Sweatt J, et al.
Neurobiol Aging
. 2013 Apr;
34(9):2081-90.
PMID: 23582659
Amyloid-β peptide (Aβ) fragment misfolding may play a crucial role in the progression of Alzheimer's disease (AD) pathophysiology as well as epigenetic mechanisms at the DNA and histone level. We...
7.
Xiao C, Davis F, Chauhan B, Viola K, Lacor P, Velasco P, et al.
J Alzheimers Dis
. 2013 Apr;
35(4):777-88.
PMID: 23542865
Alzheimer's disease (AD) is a global health crisis with limited treatment options. Despite major advances in neurotherapeutics, poor brain penetration due to the blood-brain barrier continues to pose a big...
8.
Velasco P, Heffern M, Sebollela A, Popova I, Lacor P, Lee K, et al.
ACS Chem Neurosci
. 2012 Nov;
3(11):972-81.
PMID: 23173076
Amyloid β42 self-assembly is complex, with multiple pathways leading to large insoluble fibrils or soluble oligomers. Oligomers are now regarded as most germane to Alzheimer's pathogenesis. We have investigated the...
9.
Costa R, Lacor P, Ferreira I, Resende R, Auberson Y, Klein W, et al.
Aging Cell
. 2012 Jun;
11(5):823-33.
PMID: 22708890
Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting both the hippocampus and the cerebral cortex. Reduced synaptic density that occurs early in the disease process seems to be partially...
10.
Fonte V, Dostal V, Roberts C, Gonzales P, Lacor P, Lacor P, et al.
Mol Neurodegener
. 2011 Aug;
6(1):61.
PMID: 21861874
Background: The β-amyloid peptide (Aβ) contains a Gly-XXX-Gly-XXX-Gly motif in its C-terminal region that has been proposed to form a "glycine zipper" that drives the formation of toxic Aβ oligomers....