Pascale Daran-Lapujade
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Explore the profile of Pascale Daran-Lapujade including associated specialties, affiliations and a list of published articles.
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70
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2082
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Recent Articles
1.
van den Broek M, Ortiz-Merino R, Bennis N, Wronska A, Hassing E, Daran-Lapujade P, et al.
Microbiol Resour Announc
. 2023 Dec;
13(2):e0055023.
PMID: 38132639
The biobased-economy aims to create a circular biotechnology ecosystem to transition from a fossil fuel-based to a sustainable industry based on biomass. For this, new microbial cell-factories are essential. We...
2.
Koster C, Kleefeldt A, van den Broek M, Luttik M, Daran J, Daran-Lapujade P
Yeast
. 2023 Aug;
41(4):256-278.
PMID: 37642136
Mitochondria fulfil many essential roles and have their own genome, which is expressed as polycistronic transcripts that undergo co- or posttranscriptional processing and splicing. Due to the inherent complexity and...
3.
Ridder M, van den Brandeler W, Altiner M, Daran-Lapujade P, Pabst M
Mol Cell Proteomics
. 2023 Apr;
22(6):100552.
PMID: 37076048
The yeast Saccharomyces cerevisiae is a widely-used eukaryotic model organism and a promising cell factory for industry. However, despite decades of research, the regulation of its metabolism is not yet...
4.
Postma E, Couwenberg L, van Roosmalen R, Geelhoed J, de Groot P, Daran-Lapujade P
mBio
. 2022 Sep;
13(5):e0297021.
PMID: 36129294
Saccharomyces cerevisiae, whose evolutionary past includes a whole-genome duplication event, is characterized by a mosaic genome configuration with substantial apparent genetic redundancy. This apparent redundancy raises questions about the evolutionary...
5.
Boonekamp F, Knibbe E, Vieira-Lara M, Wijsman M, Luttik M, van Eunen K, et al.
Cell Rep
. 2022 Jun;
39(13):111010.
PMID: 35767960
Although transplantation of single genes in yeast plays a key role in elucidating gene functionality in metazoans, technical challenges hamper humanization of full pathways and processes. Empowered by advances in...
6.
Koster C, Postma E, Knibbe E, Cleij C, Daran-Lapujade P
Front Bioeng Biotechnol
. 2022 Apr;
10:869486.
PMID: 35387293
Synthetic Genomics focuses on the construction of rationally designed chromosomes and genomes and offers novel approaches to study biology and to construct synthetic cell factories. Currently, progress in Synthetic Genomics...
7.
Ridder M, Knibbe E, van den Brandeler W, Daran-Lapujade P, Pabst M
J Proteomics
. 2022 Mar;
261:104576.
PMID: 35351659
The importance of obtaining comprehensive and accurate information from cellular proteomics experiments asks for a systematic investigation of sample preparation protocols. In particular when working with unicellular organisms with strong...
8.
Elsemman I, Rodriguez Prado A, Grigaitis P, Garcia Albornoz M, Harman V, Holman S, et al.
Nat Commun
. 2022 Feb;
13(1):801.
PMID: 35145105
When conditions change, unicellular organisms rewire their metabolism to sustain cell maintenance and cellular growth. Such rewiring may be understood as resource re-allocation under cellular constraints. Eukaryal cells contain metabolically...
9.
Postma E, Hassing E, Mangkusaputra V, Geelhoed J, de la Torre P, van den Broek M, et al.
Metab Eng
. 2022 Jan;
72:1-13.
PMID: 35051627
The construction of powerful cell factories requires intensive genetic engineering for the addition of new functionalities and the remodeling of native pathways and processes. The present study demonstrates the feasibility...
10.
Randazzo P, Bennis N, Daran J, Daran-Lapujade P
CRISPR J
. 2021 Apr;
4(6):896-913.
PMID: 33900846
Even for the genetically accessible yeast , the CRISPR-Cas DNA editing technology has strongly accelerated and facilitated strain construction. Several methods have been validated for fast and highly efficient single...