Paramjit S Arora
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Explore the profile of Paramjit S Arora including associated specialties, affiliations and a list of published articles.
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95
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2326
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Recent Articles
1.
Tang C, Gomez K, Chen Y, Allen H, Hestehave S, Rodriguez-Palma E, et al.
J Clin Invest
. 2024 Dec;
135(4).
PMID: 39656529
Antagonists - such as Ziconotide and Gabapentin - of the CaV2.2 (N-type) calcium channels are used clinically as analgesics for chronic pain. However, their use is limited by narrow therapeutic...
2.
Gomez K, Santiago U, Nelson T, Allen H, Calderon-Rivera A, Hestehave S, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(47):e2305215120.
PMID: 37972067
Transmembrane Ca2.2 (N-type) voltage-gated calcium channels are genetically and pharmacologically validated, clinically relevant pain targets. Clinical block of Ca2.2 (e.g., with Prialt/Ziconotide) or indirect modulation [e.g., with gabapentinoids such as...
3.
Kwok J, Yuan Z, Arora P
Angew Chem Int Ed Engl
. 2023 Aug;
62(39):e202308650.
PMID: 37548640
RNA, unlike DNA, folds into a multitude of secondary and tertiary structures. This structural diversity has impeded the development of ligands that can sequence-specifically target this biomolecule. We sought to...
4.
Nazzaro A, Lu B, Sawyer N, Watkins A, Arora P
Angew Chem Int Ed Engl
. 2023 May;
62(41):e202303943.
PMID: 37170337
Mimics of protein secondary and tertiary structure offer rationally-designed inhibitors of biomolecular interactions. β-Sheet mimics have a storied history in bioorganic chemistry and are typically designed with synthetic or natural...
5.
Qi X, Jambu S, Ji Y, Belyk K, Panigrahi N, Arora P, et al.
Angew Chem Int Ed Engl
. 2022 Sep;
61(48):e202213315.
PMID: 36175367
Radical addition to dehydroalanine (Dha) represents an appealing, modular strategy to access non-canonical peptide analogues for drug discovery. Prior studies on radical addition to the Dha residue of peptides and...
6.
Merritt H, Sawyer N, Watkins A, Arora P
ACS Chem Biol
. 2022 Sep;
17(10):2723-2727.
PMID: 36153968
Minimal protein mimics have yielded novel classes of protein-protein interaction inhibitors; however, this success has not been extended to targeting intrinsically disordered proteins, which represent a significant proportion of important...
7.
Brawley D, Sauer D, Li J, Zheng X, Koide A, Jedhe G, et al.
Nat Chem Biol
. 2022 Apr;
18(7):706-712.
PMID: 35361990
Membrane protein efflux pumps confer antibiotic resistance by extruding structurally distinct compounds and lowering their intracellular concentration. Yet, there are no clinically approved drugs to inhibit efflux pumps, which would...
8.
Handoko , Panigrahi N, Arora P
J Am Chem Soc
. 2022 Feb;
144(8):3637-3643.
PMID: 35188383
Peptides are fundamental therapeutic modalities whose sequence-specific synthesis can be automated. Yet, modern peptide synthesis remains atom uneconomical and requires an excess of coupling agents and protected amino acids for...
9.
Modell A, Marrone 3rd F, Panigrahi N, Zhang Y, Arora P
J Am Chem Soc
. 2022 Jan;
144(3):1198-1204.
PMID: 35029987
Constrained peptides have proven to be a rich source of ligands for protein surfaces, but are often limited in their binding potency. Deployment of nonnatural side chains that access unoccupied...
10.
Jedhe G, Arora P
Methods Enzymol
. 2021 Jul;
656:1-25.
PMID: 34325784
Examination of complexes of proteins with biomolecular ligands reveals that proteins tend to interact with partners via folded sub-domains, in which the backbone possesses secondary structure. α-Helices comprising the largest...