Paolo Rossato
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Explore the profile of Paolo Rossato including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
59
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Recent Articles
1.
Ruthsatz T, Wymann S, Velkoska E, Mansour M, Schu D, Lichtfuss M, et al.
Toxicol Appl Pharmacol
. 2024 Dec;
495:117191.
PMID: 39647511
CSL040 is a soluble, recombinant fragment of the complement receptor 1 (CR1) extracellular domain that acts as an inhibitor of all three pathways of the complement system. Systemic toxicity, toxicokinetics...
2.
Rossato P, Glantschnig H, Canneva F, Schuster M, Coulibaly S, Schrenk G, et al.
J Thromb Haemost
. 2023 Jan;
21(2):269-275.
PMID: 36700507
Background: Sickle cell disease (SCD) is an inherited red blood cell disorder with a causative substitution in the beta-globin gene that encodes beta-globin in hemoglobin. Furthermore, the ensuing vasculopathy in...
3.
Wymann S, Mischnik M, Leong D, Ghosh S, Tan X, Cao H, et al.
Biochem J
. 2022 Apr;
479(9):1007-1030.
PMID: 35470373
Human Complement Receptor 1 (HuCR1) is a potent membrane-bound regulator of complement both in vitro and in vivo, acting via interaction with its ligands C3b and C4b. Soluble versions of...
4.
Rossato P, Federti E, Matte A, Glantschnig H, Canneva F, Schuster M, et al.
Haematologica
. 2022 Apr;
107(11):2650-2660.
PMID: 35443560
Sickle cell disease (SCD) is an inherited red blood cell disorder that occurs worldwide. Acute vaso-occlusive crisis is the main cause of hospitalization in patients with SCD. There is growing...
5.
Searle A, Chen Y, Wallert M, McFadyen J, Maluenda A, Noonan J, et al.
Thromb Haemost
. 2021 Oct;
122(2):196-207.
PMID: 34619795
Background: 3F7 is a monoclonal antibody targeting the enzymatic pocket of activated factor XII (FXIIa), thereby inhibiting its catalytic activity. Given the emerging role of FXIIa in promoting thromboinflammation, along...
6.
Rossato P, Glantschnig H, Leidenmuhler P, Kopic A, Ruthsatz T, Majer B, et al.
Blood Coagul Fibrinolysis
. 2021 Jul;
33(1):56-60.
PMID: 34267062
Insufficiency of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin motif repeats-13) is the cause of thrombotic thrombocytopenic purpura (TTP) and contributes in microangiopathy in sickle cell disease (SCD). Recombinant ADAMTS13...
7.
Nannelli A, Rossignolo F, Tolando R, Rossato P, Pellegatti M, Longo V, et al.
Mol Cell Biochem
. 2009 Oct;
337(1-2):133-43.
PMID: 19844775
The in vivo effect of rifampicin, a potent ligand of PXR, on gene expression of CYP2B22, 3A22, 3A29, 3A46, CAR, PXR and MDR1, MRP1, MRP2, LRP transporters in liver and...
8.
Nannelli A, Rossignolo F, Tolando R, Rossato P, Longo V, Gervasi P
Toxicology
. 2009 Sep;
265(3):69-79.
PMID: 19786062
The constitutive and inducible expression of aryl hydrocarbon receptor (AhR) and of the AhR-regulated genes coding for CYP1A1, CYP1A2, CYP1B1, CYP2S1, and Nrf2 was investigated by real-time or traditional PCR...
9.
Cominacini L, Fratta Pasini A, Garbin U, Pastorino A, Davoli A, Nava C, et al.
Biochem Biophys Res Commun
. 2003 Mar;
302(4):679-84.
PMID: 12646222
Lacidipine, a dihydropyridine-based calcium antagonist (DHP), has already been demonstrated to possess antioxidant activity and to reduce the intracellular production of reactive oxygen species (ROS). To verify if this effect...