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Paola B Arimondo

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Articles 112
Citations 1813
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Recent Articles
1.
Castillo-Aguilera O, Depreux P, Halby L, Bailly C, Dominguez-Ramirez L, Gul S, et al.
RSC Med Chem . 2025 Mar; PMID: 40061000
The histone methyltransferase DOT1L (DOT1 like, disruptor of telomeric silencing) is responsible for methylation of H3K79, leading to oncogene transcription, and it is involved in the development of different types...
2.
Beljkas M, Ruzic D, Djuric A, Vuletic A, Tchiehe G, Jallet C, et al.
Future Med Chem . 2025 Jan; 17(4):393-407. PMID: 39885716
Aim: With the aim of simultaneously modulating the epigenetic system and the protein kinase pathway, we selected the enzyme histone deacetylase (HDAC) and the Rho-associated protein kinases (ROCK) as desired...
3.
Serhouni A, Calzaferri F, Bessina Y, van der Lee A, Arimondo P, Louet M, et al.
Bioorg Med Chem . 2024 Dec; 118():117988. PMID: 39689413
Flavonoid derivatives are natural product analogues that have shown great interest for therapeutic applications as modulators of DNA methylation. In this article we report new synthesis pathways to access ten...
4.
Friedrich L, Guthart A, Zhou M, Arimondo P, Efferth T, Dawood M
Int J Mol Sci . 2024 Nov; 25(22). PMID: 39595939
Targeting epigenetics is a new strategy to treat cancer and develop novel epigenetic drugs with anti-tumor activity. DNA methyltransferases transfer the methyl group from -adenosyl-L-methionine (SAM) to the cytosine residue...
5.
Barbachowska M, Harivel T, Nicchi S, Danckaert A, Ghazarian M, Chiaravalli J, et al.
Chembiochem . 2024 Sep; 25(23):e202400293. PMID: 39252664
Resistance to anti-microbial agents is a world-wide health threat. Thus, there is an urgent need for new treatments. An alternative approach to disarm pathogens consists in developing drugs targeting epigenetic...
6.
Yamaguchi K, Chen X, Rodgers B, Miura F, Bashtrykov P, Bonhomme F, et al.
Nat Commun . 2024 Apr; 15(1):2960. PMID: 38580649
DNA methylation is an essential epigenetic chromatin modification, and its maintenance in mammals requires the protein UHRF1. It is yet unclear if UHRF1 functions solely by stimulating DNA methylation maintenance...
7.
Zwergel C, Fioravanti R, Stazi G, Sarno F, Battistelli C, Romanelli A, et al.
Cancers (Basel) . 2024 Mar; 16(6). PMID: 38539577
In the original publication [...].
8.
Reyser T, Paloque L, Nguyen M, Augereau J, Fuchter M, Lopez M, et al.
Pharmaceutics . 2023 Oct; 15(10). PMID: 37896200
The use of artemisinin and its derivatives has helped reduce the burden of malaria caused by However, artemisinin-resistant parasites are able, in the presence of artemisinins, to stop their cell...
9.
Barbachowska M, Arimondo P
Epigenetics . 2023 Sep; 18(1):2242689. PMID: 37731322
Epigenetics describes chemical modifications of the genome that do not alter DNA sequence but participate in the regulation of gene expression and cellular processes such as proliferation, division, and differentiation...
10.
Canat A, Veillet A, Batrin R, Dubourg C, Lhoumaud P, Arnau-Romero P, et al.
J Cell Sci . 2023 Sep; 136(19). PMID: 37655670
Genomes comprise a large fraction of repetitive sequences folded into constitutive heterochromatin, which protect genome integrity and cell identity. De novo formation of heterochromatin during preimplantation development is an essential...