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» Authors » Pankaj Makadia

Pankaj Makadia

Explore the profile of Pankaj Makadia including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 9
Followers 0
Related Specialties
Biochemistry
Chemistry
Top 10 Co-Authors
Harikishore Pingali
Pandurang Zaware
Mukul Jain
Suresh Giri
Pankaj Patel
Shailesh Shah
Suresh Pola
Harilal Patel
Baban Thube
Megha Patel
Published In
Bioorg Med Chem Lett
Bioorg Med Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Discovery of a potent G-protein-coupled receptor 119 agonist for the treatment of type 2 diabetes
Pola S, Shah S, Pingali H, Zaware P, Thube B, Makadia P, et al.
Bioorg Med Chem . 2021 Feb; 35:116071. PMID: 33611013
The ever-growing prevalence of Type-2 diabetes in the world has an urgent need for multiple orally effective agents that can regulate glucose homeostasis. G-Protein coupled receptor 119 (GPR 119) agonists...
2.
Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists
Makadia P, Shah S, Pingali H, Zaware P, Patel D, Pola S, et al.
Bioorg Med Chem . 2011 Jan; 19(2):771-82. PMID: 21215640
A novel series of thaizole and oxazole containing phenoxy acetic acid derivatives is reported as PPAR-pan agonists. Incorporation of structurally constrained oxime-ether based linker in the chemotype of a potent...
3.
Modulation of PPAR subtype selectivity. Part 2: Transforming PPARα/γ dual agonist into α selective PPAR agonist through bioisosteric modification
Zaware P, Shah S, Pingali H, Makadia P, Thube B, Pola S, et al.
Bioorg Med Chem Lett . 2011 Jan; 21(2):628-32. PMID: 21195611
A novel series of oxime containing benzyl-1,3-dioxane-r-2-carboxylic acid derivatives (6a-k) were designed as selective PPARα agonists, through bioisosteric modification in the lipophilic tail region of PPARα/γ dual agonist. Some of...
4.
Design and synthesis of novel bis-oximinoalkanoic acids as potent PPAR alpha agonists
Pingali H, Jain M, Shah S, Zaware P, Makadia P, Pola S, et al.
Bioorg Med Chem Lett . 2009 Dec; 20(3):1156-61. PMID: 20022492
Bis-oximinoalkanoic acid derivatives were designed and synthesized to aid in the characterization of selective PPARalpha agonists by replacing the oxazole ring with flexible oximino group in the lipophilic tail part...
5.
Modulation of PPAR receptor subtype selectivity of the ligands: aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety
Pingali H, Jain M, Shah S, Patil P, Makadia P, Zaware P, et al.
Bioorg Med Chem Lett . 2008 Nov; 18(24):6471-5. PMID: 18976908
Oxazole containing glycine and oximinobutyric acid derivatives were synthesized as PPARalpha agonists by incorporating polymethylene spacer as a replacement of commonly used phenylene group that connects the acidic head with...
6.
Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent
Pingali H, Jain M, Shah S, Basu S, Makadia P, Goswami A, et al.
Bioorg Med Chem Lett . 2008 Sep; 18(20):5586-90. PMID: 18805005
A series of novel 1,3-dioxane-2-carboxylic acid derivatives containing alkyl chain tether and substituted phenyl group as a lipophilic tail have been prepared as agonists of PPARalpha and gamma. c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid...
7.
Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists
Pingali H, Jain M, Shah S, Makadia P, Zaware P, Goel A, et al.
Bioorg Med Chem . 2008 Jul; 16(15):7117-27. PMID: 18625559
A few novel 1,3-dioxane carboxylic acid derivatives were designed and synthesized to aid in the characterization of PPAR alpha/gamma dual agonists. Structural requirements for PPARalpha/gamma dual agonism of 1,3-dioxane carboxylic...