Pablo D Becker
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Explore the profile of Pablo D Becker including associated specialties, affiliations and a list of published articles.
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40
Citations
1116
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Recent Articles
1.
OBrien H, Salm M, Morton L, Szukszto M, OFarrell F, Boulton C, et al.
PLoS Comput Biol
. 2024 Nov;
20(11):e1012511.
PMID: 39527593
Neoantigen immunogenicity prediction is a highly challenging problem in the development of personalised medicines. Low reactivity rates in called neoantigens result in a difficult prediction scenario with limited training datasets....
2.
OBrien H, Salm M, Morton L, Szukszto M, OFarrell F, Boulton C, et al.
Nat Cancer
. 2024 Apr;
5(4):692.
PMID: 38622449
No abstract available.
3.
OBrien H, Salm M, Morton L, Szukszto M, OFarrell F, Boulton C, et al.
Nat Cancer
. 2023 Dec;
4(12):1618-1621.
PMID: 38102360
No abstract available.
4.
Au L, Hatipoglu E, Robert de Massy M, Litchfield K, Beattie G, Rowan A, et al.
Cancer Cell
. 2021 Oct;
39(11):1497-1518.e11.
PMID: 34715028
ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma (ccRCC) aiming to understand the...
5.
Fanelli G, Romano M, Nova-Lamperti E, Sunderland M, Nerviani A, Scotta C, et al.
PLoS Biol
. 2021 Apr;
19(4):e3001199.
PMID: 33901179
Programmed cell death protein 1 (PD-1) is expressed on T cells upon T cell receptor (TCR) stimulation. PD-1 ligand 1 (PD-L1) is expressed in most tumor environments, and its binding...
6.
Ghorani E, Reading J, Henry J, Robert de Massy M, Rosenthal R, Turati V, et al.
Nat Cancer
. 2020 Aug;
1(5):546-561.
PMID: 32803172
Tumour mutational burden (TMB) predicts immunotherapy outcome in non-small cell lung cancer (NSCLC), consistent with immune recognition of tumour neoantigens. However, persistent antigen exposure is detrimental for T cell function....
7.
Becker P, Ratnasothy K, Sen M, Peng Q, Romano M, Bazoer J, et al.
Am J Transplant
. 2020 Jun;
21(4):1415-1426.
PMID: 32483894
B cells have been implicated in transplant rejection via antibody-mediated mechanisms and more recently by presenting donor antigens to T cells. We have shown in patients with chronic antibody-mediated rejection...
8.
Zaric M, Becker P, Hervouet C, Kalcheva P, Doszpoly A, Blattman N, et al.
Nat Commun
. 2019 May;
10(1):2214.
PMID: 31101810
CD8 T cells provide a critical defence from pathogens at mucosal epithelia including the female reproductive tract (FRT). Mucosal immunisation is considered essential to initiate this response, however this is...
9.
Povoleri G, Nova-Lamperti E, Scotta C, Fanelli G, Chen Y, Becker P, et al.
Nat Immunol
. 2018 Nov;
19(12):1403-1414.
PMID: 30397350
Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we describe CD161 regulatory T (T) cells as a...
10.
Emmerson A, Trevelin S, Mongue-Din H, Becker P, Ortiz C, Smyth L, et al.
J Clin Invest
. 2018 Apr;
128(7):3088-3101.
PMID: 29688896
The superoxide-generating enzyme Nox2 contributes to hypertension and cardiovascular remodeling triggered by activation of the renin-angiotensin system. Multiple Nox2-expressing cells are implicated in angiotensin II-induced (Ang II-induced) pathophysiology, but the...