P van der Geer
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Explore the profile of P van der Geer including associated specialties, affiliations and a list of published articles.
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33
Citations
2292
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Recent Articles
11.
Li S, Lai K, Gish G, Parris W, van der Geer P, Pawson T
J Biol Chem
. 1996 Dec;
271(50):31855-62.
PMID: 8943228
The phosphotyrosine-binding (PTB) domain of Drosophila Shc (dShc) binds in vitro to phosphopeptides containing the sequence motif NPXpY, and physically associates with the activated Drosophila epidermal growth factor receptor homologue...
12.
Piao X, Paulson R, van der Geer P, Pawson T, Bernstein A
Proc Natl Acad Sci U S A
. 1996 Dec;
93(25):14665-9.
PMID: 8962111
Activating mutations in the Kit receptor tyrosine kinase have been identified in both rodent and human mast cell leukemia. One activating Kit mutation substitutes a valine for aspartic acid at...
13.
van der Geer P, Wiley S, Gish G, Pawson T
Curr Biol
. 1996 Nov;
6(11):1435-44.
PMID: 8939605
Background: Signal transduction initiated by a wide variety of extracellular signals involves the activation of protein-tyrosine kinases. Phosphorylated tyrosine residues in activated receptors or docking proteins then function as binding...
14.
van der Geer P, Wiley S, Gish G, Lai V, Stephens R, White M, et al.
Proc Natl Acad Sci U S A
. 1996 Feb;
93(3):963-8.
PMID: 8577769
The Shc adaptor protein contains two phosphotyrosine [Tyr(P)]binding modules--an N-terminal Tyr(P) binding (PTB) domain and a C-terminal Src homology 2 (SH2) domain. We have compared the ability of the Shc...
15.
Rozakis-Adcock M, van der Geer P, Mbamalu G, Pawson T
Oncogene
. 1995 Oct;
11(7):1417-26.
PMID: 7478566
The mouse protein mSos1 has a central Ras guanine nucleotide exchange domain, and a long proline-rich C-terminal tail which contains several potential binding sites for the SH3 domains of the...
16.
van der Geer P, Pawson T
Trends Biochem Sci
. 1995 Jul;
20(7):277-80.
PMID: 7545337
Src homology 2 (SH2) domains have been identified in a large number of proteins involved in signal transduction downstream of receptor tyrosine kinases. They allow cytoplasmic signalling proteins to bind...
17.
Tracy S, van der Geer P, Hunter T
J Biol Chem
. 1995 May;
270(18):10587-94.
PMID: 7537734
To determine whether the receptor-like protein-tyrosine phosphatase, RPTP alpha, which is widely expressed in both the developing and adult mouse, is regulated by phosphorylation, we raised antiserum against a C-terminal...
18.
van der Geer P, Wiley S, Lai V, Olivier J, Gish G, Stephens R, et al.
Curr Biol
. 1995 Apr;
5(4):404-12.
PMID: 7542991
Background: Signal transduction by growth factor receptor protein-tyrosine kinases is generally initiated by autophosphorylation on tyrosine residues following ligand binding. Phosphotyrosines within activated receptors form binding sites for the Src...
19.
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
Schlaepfer D, Hanks S, Hunter T, van der Geer P
Nature
. 1994 Dec;
372(6508):786-91.
PMID: 7997267
The cytoplasmic focal adhesion protein-tyrosine kinase (FAK) localizes with surface integrin receptors at sites where cells attach to the extracellular matrix. Increased FAK tyrosine phosphorylation occurs upon integrin engagement with...
20.
Trautwein C, van der Geer P, Karin M, Hunter T, Chojkier M
J Clin Invest
. 1994 Jun;
93(6):2554-61.
PMID: 8200992
LAP (NF-IL6 or C/EBP beta), is a liver transcriptional activator protein that confers liver-specific gene expression. Because LAP has a characteristic phosphoacceptor sequence for cAMP-dependent protein kinase A (PKA), we...