P van der Geer
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Explore the profile of P van der Geer including associated specialties, affiliations and a list of published articles.
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33
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2292
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Recent Articles
1.
Meisenhelder J, Hunter T, van der Geer P
Curr Protoc Protein Sci
. 2008 Apr;
Chapter 13:Unit13.9.
PMID: 18429120
Protein phosphorylation is a common modification for many proteins in the cell. Phosphorylation can affect localization of a protein, its stability, and its ability to dimerize or form stable complexes...
2.
Meisenhelder J, Hunter T, van der Geer P
Curr Protoc Mol Biol
. 2008 Feb;
Chapter 18:Unit 18.9.
PMID: 18265174
This unit describes a procedure for proteolytic digestion of a (32)P-labeled protein, followed by separation of the digestion products in two dimensions on a TLC plate, which gives rise to...
3.
Tourriere H, Gallouzi I, Chebli K, Capony J, Mouaikel J, van der Geer P, et al.
Mol Cell Biol
. 2001 Oct;
21(22):7747-60.
PMID: 11604510
Mitogen activation of mRNA decay pathways likely involves specific endoribonucleases, such as G3BP, a phosphorylation-dependent endoribonuclease that associates with RasGAP in dividing but not quiescent cells. G3BP exclusively cleaves between...
4.
Barnes H, LARSEN B, Tyers M, van der Geer P
J Biol Chem
. 2001 Mar;
276(22):19119-25.
PMID: 11259429
v-Src transforms fibroblasts in vitro and causes tumor formation in the animal by tyrosine phosphorylation of critical cellular substrates. Exactly how v-Src interacts with these substrates remains unknown. One of...
5.
Velazquez L, Gish G, van der Geer P, Taylor L, SHULMAN J, Pawson T
Blood
. 2000 Jul;
96(1):132-8.
PMID: 10891441
The Shc adaptor protein possesses 2 distinct phosphotyrosine (pTyr) recognition modules-the pTyr binding (PTB) domain and the Src homology 2 (SH2) domain-and multiple potential sites for tyrosine (Tyr) phosphorylation (Tyr...
6.
Kulkarni S, Gish G, van der Geer P, Henkemeyer M, Pawson T
J Cell Biol
. 2000 Apr;
149(2):457-70.
PMID: 10769036
We have used cell lines deficient in p120 Ras GTPase activating protein (Ras-GAP) to investigate the roles of Ras-GAP and the associated p190 Rho-GAP (p190) in cell polarity and cell...
7.
Buck M, Poli V, van der Geer P, Chojkier M, Hunter T
Mol Cell
. 2000 Jan;
4(6):1087-92.
PMID: 10635333
We report that TGF alpha induces activation of the p90 ribosomal S kinase (RSK), which results in the phosphorylation of rat C/EBP beta on Ser-105 and of mouse C/EBP beta...
8.
Ingham R, Okada H, Dinglasan J, van der Geer P, Kurosaki T, Gold M
J Immunol
. 1999 Nov;
163(11):5891-5.
PMID: 10570274
Tyrosine phosphorylation of Shc in response to B cell Ag receptor (BCR) engagement creates binding sites for the Src homology 2 (SH2) domain of Grb2. This facilitates the recruitment of...
9.
van der Geer P, Wiley S, Pawson T
Oncogene
. 1999 May;
18(20):3071-5.
PMID: 10340378
Shc and IRS-1 (and their relatives) are cytoplasmic docking proteins that possess phosphotyrosine-binding (PTB) domains, through which they bind specific activated receptor tyrosine kinases (RTK). The subsequent phosphorylation of Shc...
10.
van der Geer P, Henkemeyer M, Jacks T, Pawson T
Mol Cell Biol
. 1997 Apr;
17(4):1840-7.
PMID: 9121432
The Ras guanine nucleotide-binding protein functions as a molecular switch in signalling downstream of protein-tyrosine kinases. Ras is activated by exchange of GDP for GTP and is turned off by...