P V Narasimha Reddy
Overview
Explore the profile of P V Narasimha Reddy including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
194
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Recent Articles
1.
Beck D, Reddy P, Lv W, Abdelmalak M, Tender G, Lopez S, et al.
J Med Chem
. 2016 Apr;
59(8):3840-53.
PMID: 27070999
Several indenoisoquinolines have shown promise as anticancer agents in clinical trials. Incorporation of a nitrogen atom into the indenoisoquinoline scaffold offers the possibility of favorably modulating ligand-binding site interactions, physicochemical...
2.
Mohammad H, Reddy P, Monteleone D, Mayhoub A, Cushman M, Hammac G, et al.
PLoS One
. 2015 Jun;
10(6):e0130385.
PMID: 26086336
Staphylococcus pseudintermedius is a commensal organism of companion animals that is a significant source of opportunistic infections in dogs. With the emergence of clinical isolates of S. pseudintermedius (chiefly methicillin-resistant...
3.
Beck D, Abdelmalak M, Lv W, Reddy P, Tender G, ONeill E, et al.
J Med Chem
. 2015 Apr;
58(9):3997-4015.
PMID: 25909279
3-Nitroindenoisoquinoline human topoisomerase IB (Top1) poisons have potent antiproliferative effects on cancer cells. The undesirable nitro toxicophore could hypothetically be replaced by other functional groups that would retain the desired...
4.
Roy J, Nguyen T, Kanduluru A, Venkatesh C, Lv W, Reddy P, et al.
J Med Chem
. 2015 Mar;
58(7):3094-103.
PMID: 25822623
Prostate-specific membrane antigen (PSMA) is overexpressed in most prostate cancer cells while being present at low or undetectable levels in normal cells. This difference provides an opportunity to selectively deliver...
5.
Mohammad H, Reddy P, Monteleone D, Mayhoub A, Cushman M, Seleem M
Eur J Med Chem
. 2015 Mar;
94:306-16.
PMID: 25771109
Methicillin-resistant Staphylococcus aureus infections are a significant global health challenge in part due to the emergence of strains exhibiting resistance to nearly all classes of antibiotics. This underscores the urgent...
6.
Conda-Sheridan M, Park E, Beck D, Reddy P, Nguyen T, Hu B, et al.
J Med Chem
. 2013 Mar;
56(6):2581-605.
PMID: 23472886
Nuclear receptors, such as the retinoid X receptor (RXR), are proteins that regulate a myriad of cellular processes. Molecules that function as RXR agonists are of special interest for the...
7.
Conda-Sheridan M, Reddy P, Morrell A, Cobb B, Marchand C, Agama K, et al.
J Med Chem
. 2012 Dec;
56(1):182-200.
PMID: 23259865
Tyrosyl-DNA phosphodiesterase I (Tdp1) plays a key role in the repair of damaged DNA resulting from the topoisomerase I (Top1) inhibitor camptothecin and a variety of other DNA-damaging anticancer agents....
8.
Cinelli M, Reddy P, Lv P, Liang J, Chen L, Agama K, et al.
J Med Chem
. 2012 Dec;
55(24):10844-62.
PMID: 23215354
Hydroxylated analogues of the anticancer topoisomerase I (Top1) inhibitors indotecan (LMP400) and indimitecan (LMP776) have been prepared because (1) a variety of potent Top1 poisons are known that contain strategically...
9.
Chen L, Conda-Sheridan M, Reddy P, Morrell A, Park E, Kondratyuk T, et al.
J Med Chem
. 2012 Jun;
55(12):5965-81.
PMID: 22712432
Activation of the retinoid X receptor (RXR), which is involved in cell proliferation, differentiation, and apoptosis, is a strategy for cancer chemotherapy and chemoprevention, and 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36) (3) is among...
10.
Reddy P, Jensen K, Mesecar A, Fanwick P, Cushman M
J Med Chem
. 2011 Dec;
55(1):367-77.
PMID: 22206487
A variety of ammosamide B analogues have been synthesized and evaluated as inhibitors of quinone reductase 2 (QR2). The potencies of the resulting series of QR2 inhibitors range from 4.1...