P T Mannisto
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Explore the profile of P T Mannisto including associated specialties, affiliations and a list of published articles.
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208
Citations
1498
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Recent Articles
1.
Boku S, Izumi T, Abe S, Takahashi T, Nishi A, Nomaru H, et al.
Mol Psychiatry
. 2017 Aug;
23(4):985-992.
PMID: 28827761
Working memory capacity, a critical component of executive function, expands developmentally from childhood through adulthood. Anomalies in this developmental process are seen in individuals with autism spectrum disorder (ASD), schizophrenia...
2.
Tammimaki A, Aonurm-Helm A, Zhang F, Poutanen M, Duran-Torres G, Garcia-Horsman A, et al.
J Physiol Pharmacol
. 2017 Feb;
67(6):827-842.
PMID: 28195063
Catechol-O-methyltransferase (COMT) has two isoforms: soluble (S-COMT), which resides in the cytoplasm, and membrane-bound (MB-MT), anchored to intracellular membranes. COMT is involved in the O-methylation of L-DOPA, dopamine and other...
3.
Tammimaki A, Aonurm-Helm A, Kaenmaki M, Mannisto P
J Physiol Pharmacol
. 2016 May;
67(2):301-9.
PMID: 27226189
We have shown in a previous study that in the medial prefrontal cortex (mPFC) of Comt knockout animals, uptake1 followed by oxidation accounts for approximately 50% and uptake2 followed by...
4.
Hannula M, Myohanen T, Tenorio-Laranga J, Mannisto P, Garcia-Horsman J
Neuroscience
. 2013 Apr;
242:140-50.
PMID: 23562579
Prolyl oligopeptidase (EC 3.4.21.26, PREP) is a serine protease that hydrolyzes proline-containing peptides shorter than 30-mer but it has also nonhydrolytic functions. PREP has been shown to accelerate aggregation of...
5.
Piltonen M, Savolainen M, Patrikainen S, Baekelandt V, Myohanen T, Mannisto P
Neuroscience
. 2012 Dec;
231:157-68.
PMID: 23219665
Three point mutations in the SNCA gene encoding α-synuclein (aSyn) have been associated with autosomal dominant forms of Parkinson's disease. To better understand the role of the A30P mutant aSyn,...
6.
Peltonen I, Myohanen T, Mannisto P
Neurochem Res
. 2012 Jun;
37(9):2033-41.
PMID: 22729983
Prolyl oligopeptidase (PREP) is an intracellular enzyme digesting small proline-containing peptides. Since PREP resides the same brain areas as neurotensin in the nigrostriatal and mesolimbic dopaminergic pathways, we were interested...
7.
Myohanen T, Hannula M, Van Elzen R, Gerard M, Van der Veken P, Garcia-Horsman J, et al.
Br J Pharmacol
. 2012 Jan;
166(3):1097-113.
PMID: 22233220
Background And Purpose: The aggregation of α-synuclein is connected to the pathology of Parkinson's disease and prolyl oligopeptidase (PREP) accelerates the aggregation of α-synuclein in vitro. The aim of this...
8.
Schendzielorz N, Rysa A, Reenila I, Raasmaja A, Mannisto P
J Physiol Pharmacol
. 2011 Nov;
62(4):483-90.
PMID: 22100850
Catechol-O-methyltransferase (COMT) activity depends on gender, age and physiological status suggesting that estrogen may regulate COMT activity. In fact, estrogens down-regulate the function of COMT promoters in cell cultures. On...
9.
Piltonen M, Planken A, Leskela O, Myohanen T, Hanninen A, Auvinen P, et al.
Neuroscience
. 2011 Jul;
192:550-63.
PMID: 21767614
Neurotrophic factors regulate the development and maintenance of the nervous system and protect and repair dopaminergic neurons in animal models of Parkinson's disease (PD). Vascular endothelial growth factors A (VEGF-A)...
10.
Rauhavirta T, Qiao S, Jiang Z, Myrsky E, Loponen J, Korponay-Szabo I, et al.
Clin Exp Immunol
. 2011 Jan;
164(1):127-36.
PMID: 21235541
In coeliac disease, the intake of dietary gluten induces small-bowel mucosal damage and the production of immunoglobulin (Ig)A class autoantibodies against transglutaminase 2 (TG2). We examined the effect of coeliac...