P St George-Hyslop
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Explore the profile of P St George-Hyslop including associated specialties, affiliations and a list of published articles.
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78
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5696
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Recent Articles
11.
McLaurin J, Cecal R, Kierstead M, Tian X, Phinney A, Manea M, et al.
Nat Med
. 2002 Oct;
8(11):1263-9.
PMID: 12379850
Immunization of transgenic mouse models of Alzheimer disease using amyloid-beta peptide (Abeta) reduces both the Alzheimer disease-like neuropathology and the spatial memory impairments of these mice. However, a therapeutic trial...
12.
Rozmahel R, Huang J, Chen F, Liang Y, Nguyen V, Ikeda M, et al.
Neurobiol Aging
. 2002 Jan;
23(2):187-94.
PMID: 11804702
Presenilin 1-null mice die at birth from brain and skeletal developmental deformities due to disrupted Notch signaling. Presenilin 1-null mice also have severely reduced gamma-secretase cleavage of betaAPP. The assumption...
13.
Fergani A, Yu G, St George-Hyslop P, Checler F
Biochem Biophys Res Commun
. 2001 Dec;
289(3):678-80.
PMID: 11726200
Nicastrin is a recently discovered protein interacting with presenilins and the beta-amyloid precursor protein, the proteins playing key roles in Alzheimer's disease and which, when mutated, appear responsible for early-onset...
14.
Athan E, Williamson J, Ciappa A, Santana V, Romas S, Lee J, et al.
JAMA
. 2001 Nov;
286(18):2257-63.
PMID: 11710891
Context: Genetic determinants of Alzheimer disease (AD) have not been comprehensively examined in Caribbean Hispanics, a population in the United States in whom the frequency of AD is higher compared...
15.
Rogaeva E, Fafel K, Song Y, Medeiros H, Sato C, Liang Y, et al.
Neurology
. 2001 Aug;
57(4):621-5.
PMID: 11524469
Background: Mutations in the presenilin-1 gene (PS1) account for a majority of patients with early-onset familial AD. However, the clinical indications and algorithms for genetic testing in dementia are still...
16.
Houlden H, Baker M, Morris H, Macdonald N, Pickering-Brown S, Adamson J, et al.
Neurology
. 2001 Jun;
56(12):1702-6.
PMID: 11425937
Objective: To analyze the association of polymorphisms in the tau gene with pathologically confirmed corticobasal degeneration (CBD). Background: The authors previously described an extended tau haplotype (H1) that covers the...
17.
Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, et al.
Acta Neurol Scand Suppl
. 2001 Mar;
176:6-11.
PMID: 11261807
Presenilin (PS1 and PS2) holoproteins are transiently incorporated into low molecular weight (MW) complexes. During subsequent incorporation into a higher MW complex, they undergo endoproteolysis to generate stable N- and...
18.
Pei Y, Paterson A, Wang K, He N, Hefferton D, Watnick T, et al.
Am J Hum Genet
. 2001 Jan;
68(2):355-63.
PMID: 11156533
In searching for a putative third gene for autosomal dominant polycystic kidney disease (ADPKD), we studied the genetic inheritance of a large family (NFL10) previously excluded from linkage to both...
19.
Janus C, Pearson J, McLaurin J, Mathews P, Jiang Y, Schmidt S, et al.
Nature
. 2001 Jan;
408(6815):979-82.
PMID: 11140685
Much evidence indicates that abnormal processing and extracellular deposition of amyloid-beta peptide (A beta), a proteolytic derivative of the beta-amyloid precursor protein (betaAPP), is central to the pathogenesis of Alzheimer's...
20.
Grilli M, Diodato E, Lozza G, Brusa R, Casarini M, Uberti D, et al.
Proc Natl Acad Sci U S A
. 2000 Nov;
97(23):12822-7.
PMID: 11070093
A direct pathophysiological role of Familial Alzheimer's Disease (FAD)-associated Presenilin 1 (PS1) mutations in neuronal vulnerability remains a controversial matter. We evaluated the relationship between PS1 and excitotoxicity in four...