P R Pentel
Overview
Explore the profile of P R Pentel including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
88
Citations
1137
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Raleigh M, King S, Baruffaldi F, Saykao A, Hamid F, Winston S, et al.
Neuropharmacology
. 2021 Jun;
195:108653.
PMID: 34126123
Therapeutic vaccines offer a viable strategy to treat opioid use disorders (OUD) complementary to current pharmacotherapies. The candidate Oxy(Gly)-sKLH vaccine targeting oxycodone displayed pre-clinical proof of efficacy, selectivity and safety,...
2.
Baruffaldi F, Raleigh M, King S, Roslawski M, Birnbaum A, Hassler C, et al.
Mol Pharm
. 2019 Apr;
16(6):2364-2375.
PMID: 31018096
This study focused on formulating conjugate vaccines targeting oxycodone and heroin for technology transfer, good manufacturing practice (GMP), and clinical evaluation. Lead vaccines used the highly immunogenic carrier protein keyhole...
3.
Raleigh M, Peterson S, Laudenbach M, Baruffaldi F, Carroll F, Comer S, et al.
PLoS One
. 2017 Dec;
12(12):e0184876.
PMID: 29194445
Among vaccines aimed at treating substance use disorders, those targeting opioids present several unique medication development challenges. 1) Opioid overdose is a common complication of abuse, so it is desirable...
4.
Lesage M, Staley M, Muelken P, Smethells J, Stepanov I, Vogel R, et al.
Drug Alcohol Depend
. 2016 Sep;
168:76-88.
PMID: 27627814
Background: The popularity of electronic cigarettes (ECs) has increased dramatically despite their unknown health consequences. Because the abuse liability of ECs is one of the leading concerns of the Food...
5.
De Biasi M, McLaughlin I, Perez E, Crooks P, Dwoskin L, Bardo M, et al.
Drug Alcohol Depend
. 2014 Jun;
141:107-17.
PMID: 24934691
Nicotine dependence plays a critical role in addiction to tobacco products, and thus contributes to a variety of devastating tobacco-related diseases (SGR 2014). Annual costs associated with smoking in the...
6.
Raleigh M, Pravetoni M, Harris A, Birnbaum A, Pentel P
J Pharmacol Exp Ther
. 2012 Dec;
344(2):397-406.
PMID: 23220743
Morphine conjugate vaccines have effectively reduced behavioral effects of heroin in rodents and primates. To better understand how these effects are mediated, heroin and metabolite distribution studies were performed in...
7.
Pravetoni M, Raleigh M, Le Naour M, Tucker A, Harmon T, Jones J, et al.
Vaccine
. 2012 May;
30(31):4617-24.
PMID: 22583811
Opioid conjugate vaccines have shown promise in animal models as a potential treatment for opioid addiction. Individual vaccines are quite specific and each targets only a limited number of structurally...
8.
Pravetoni M, Le Naour M, Harmon T, Tucker A, Portoghese P, Pentel P
J Pharmacol Exp Ther
. 2012 Jan;
341(1):225-32.
PMID: 22262924
Opioid conjugate vaccines have shown promise in attenuating the behavioral effects of heroin or morphine in animals. The goal of this study was to extend this approach to oxycodone (OXY),...
9.
Pravetoni M, Keyler D, Pidaparthi R, Carroll F, Runyon S, Murtaugh M, et al.
Biochem Pharmacol
. 2011 Nov;
83(4):543-50.
PMID: 22100986
Nicotine conjugate vaccine efficacy is limited by the concentration of nicotine-specific antibodies that can be reliably generated in serum. Previous studies suggest that the concurrent use of 2 structurally distinct...
10.
Pravetoni M, Keyler D, Raleigh M, Harris A, Lesage M, Mattson C, et al.
Biochem Pharmacol
. 2011 Feb;
81(9):1164-70.
PMID: 21333633
Preclinical models of nicotine vaccine pharmacology have relied on i.v. or s.c. administration of nicotine. Models using cigarette smoke inhalation might more accurately simulate nicotine exposure in smokers. Nicotine vaccine...