P R Pentel
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Explore the profile of P R Pentel including associated specialties, affiliations and a list of published articles.
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88
Citations
1137
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Recent Articles
11.
Keyler D, Roiko S, Earley C, Murtaugh M, Pentel P
Int Immunopharmacol
. 2008 Jul;
8(11):1589-94.
PMID: 18656557
The efficacy of nicotine vaccines for smoking cessation is dependent upon their ability to elicit sufficiently high serum antibody concentrations. This study compared two nicotine immunogens representing different hapten presentations,...
12.
Pentel P, Keyler D, Chen Y, Lesage M, Dufek M, Le C, et al.
Neurotoxicol Teratol
. 2006 Sep;
28(5):589-96.
PMID: 16996246
Gestational exposure of rats to nicotine produces long-lasting alterations in brain development. Vaccination of adult female rats against nicotine reduces the distribution of maternally administered nicotine to fetal brain, suggesting...
13.
Keyler D, Lesage M, Dufek M, Pentel P
Int Immunopharmacol
. 2006 Sep;
6(11):1665-72.
PMID: 16979120
Vaccination against nicotine to elicit the production of nicotine-specific antibodies is a potential treatment for tobacco addiction which reduces nicotine distribution from serum to brain. Vaccination of pregnant rats also...
14.
Pentel P, Dufek M, Roiko S, Lesage M, Keyler D
J Pharmacol Exp Ther
. 2006 Jan;
317(2):660-6.
PMID: 16407464
Vaccination against nicotine blocks or attenuates nicotine-related behaviors relevant to addiction in rats. Passive immunization with nicotine-specific antibodies is an alternative to vaccination with the potential advantages of allowing control...
15.
Keyler D, Roiko S, Benlhabib E, Lesage M, St Peter J, Stewart S, et al.
Drug Metab Dispos
. 2005 Apr;
33(7):1056-61.
PMID: 15843487
Vaccination against nicotine is being studied as a potential treatment for nicotine dependence. Some of the limitations of vaccination, such as variability in antibody titer and affinity, might be overcome...
16.
Satoskar S, Keyler D, Lesage M, Raphael D, Ross C, Pentel P
Int Immunopharmacol
. 2003 Jun;
3(7):957-70.
PMID: 12810353
Vaccination of rats against nicotine reduces nicotine distribution to brain even at nicotine doses greatly exceeding the estimated binding capacity of the available antibody. This observation suggests a differential effect...
17.
Hatsukami D, Hecht S, Hennrikus D, Joseph A, Pentel P
Nicotine Tob Res
. 2003 Jun;
5(3):387-96.
PMID: 12791522
Adverse outcomes from tobacco use may take decades to develop. Biomarkers are measures that can be used in the early stages of tobacco use to assess exposure to tobacco toxins...
18.
Hennrikus D, Pentel P, Sandell S
Tob Control
. 2003 May;
12(2):189-94.
PMID: 12773730
Objective: This study assessed renters' preferences for official smoking policies in their buildings and their practices concerning restricting tobacco smoking in their apartments. Design: Renters (n = 301) living in...
19.
Keyler D, Shoeman D, Lesage M, Calvin A, Pentel P
J Pharmacol Exp Ther
. 2003 Feb;
305(2):587-92.
PMID: 12606612
Cigarette smoking during pregnancy is associated with a variety of adverse fetal outcomes. Nicotine is a likely contributor to these adverse effects, with fetal brain as one target organ. Vaccination...
20.
Tuncok Y, Hieda Y, Keyler D, Brown S, Ennifar S, Fattom A, et al.
Exp Clin Psychopharmacol
. 2001 Aug;
9(2):228-34.
PMID: 11518099
The ability of a nicotine vaccine to protect against nicotine-induced seizures was studied in rats. Groups of 10 rats were vaccinated with 3 doses of either a nicotine conjugate vaccine...