P R Hartig
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Explore the profile of P R Hartig including associated specialties, affiliations and a list of published articles.
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67
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1812
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Recent Articles
1.
Hartig P, Evans M, Krohn A, Leder S, Sze P, Stoffers D
Neurochem Int
. 2010 May;
7(4):699-707.
PMID: 20492977
[(125)I]LSD (labeled at the 2 position) has been introduced as the first (125)I-labeled ligand for serotonin 5-HT(2) (S2) receptors. In the present study we examined the binding of [(125)I]LSD and...
2.
Ho S, Hartig P
Curr Opin Mol Ther
. 2001 Nov;
1(3):336-43.
PMID: 11713799
Although antisense oligonucleotides have been used in cell-based antisense experiments for nearly two decades, studies to investigate the function of CNS proteins in living animals were not successfully conducted until...
3.
Ho S, Takahashi L, Livanov V, Spencer K, Lesher T, Maciag C, et al.
Brain Res Mol Brain Res
. 2001 Apr;
89(1-2):29-40.
PMID: 11311973
Corticotropin releasing factor (CRF) is an important regulator of the endocrine, behavioral, autonomic and immune responses to stress. Two high affinity CRF receptors have been identified, which are distributed in...
4.
Seiffert D, Bradley J, Rominger C, Rominger D, Yang F, Meredith Jr J, et al.
J Biol Chem
. 2000 Aug;
275(44):34086-91.
PMID: 10915801
Presenilins are integral membrane protein involved in the production of amyloid beta-protein. Mutations of the presenilin-1 and -2 gene are associated with familial Alzheimer's disease and are thought to alter...
5.
Fitzgerald L, Burn T, Brown B, Patterson J, Corjay M, VALENTINE P, et al.
Mol Pharmacol
. 2000 Jan;
57(1):75-81.
PMID: 10617681
Dexfenfluramine was approved in the United States for long-term use as an appetite suppressant until it was reported to be associated with valvular heart disease. The valvular changes (myofibroblast proliferation)...
6.
Fitzgerald L, Iyer G, Conklin D, Krause C, Marshall A, Patterson J, et al.
Neuropsychopharmacology
. 1999 Aug;
21(2 Suppl):82S-90S.
PMID: 10432493
RNA encoding the rat serotonin 5-HT2C receptor undergoes editing whereby one to four adenosines are converted to inosines. This conversion can change up to three codons out of a stretch...
7.
Fitzgerald L, Conklin D, Krause C, Marshall A, Patterson J, Tran D, et al.
J Neurochem
. 1999 Apr;
72(5):2127-34.
PMID: 10217294
Many modern models of receptor-G protein function assume that there is a direct relationship between high-affinity agonist binding and efficacy. The validity of this assumption has been recently questioned for...
8.
Grzanna R, Dubin J, Dent G, Ji Z, Zhang W, Ho S, et al.
Brain Res Mol Brain Res
. 1998 Dec;
63(1):35-52.
PMID: 9838035
We have determined the time course, the spatial spread in brain tissue, and the intracellular distribution of biotin- and fluorescein-labeled phosphorothioate oligodeoxynucleotides (ODNs) following single injections into the rat striatum...
9.
10.
Hartig P, Hoyer D, Humphrey P, Martin G
Trends Pharmacol Sci
. 1996 Mar;
17(3):103-5.
PMID: 8936345
The continuing rapid progress towards a complete database of structural information on the human genome creates a challenge of ensuring that current schemes for classifying and naming receptors and ion...