P R Griffin
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Explore the profile of P R Griffin including associated specialties, affiliations and a list of published articles.
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51
Citations
2281
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Recent Articles
1.
Sanulli S, Trnka M, Dharmarajan V, Tibble R, Pascal B, Burlingame A, et al.
Nature
. 2019 Oct;
575(7782):390-394.
PMID: 31618757
Heterochromatin affects genome function at many levels. It enables heritable gene repression, maintains chromosome integrity and provides mechanical rigidity to the nucleus. These diverse functions are proposed to arise in...
2.
Pettersson-Klein A, Izadi M, Ferreira D, Cervenka I, Correia J, Martinez-Redondo V, et al.
Mol Metab
. 2018 Feb;
9:28-42.
PMID: 29428596
Objective: The peroxisome proliferator-activated receptor-γ coactivator-1α1 (PGC-1α1) regulates genes involved in energy metabolism. Increasing adipose tissue energy expenditure through PGC-1α1 activation is potentially beneficial for systemic metabolism. Pharmacological PGC-1α1 activators...
3.
Stechschulte L, Czernik P, Rotter Z, Tausif F, Corzo C, Marciano D, et al.
EBioMedicine
. 2016 Jul;
10:174-84.
PMID: 27422345
The peroxisome proliferator-activated receptor gamma (PPARγ) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. However, clinical...
4.
Pascal B, Chalmers M, Busby S, Mader C, Southern M, Tsinoremas N, et al.
BMC Bioinformatics
. 2007 May;
8:156.
PMID: 17506883
Background: The combination of mass spectrometry and solution phase amide hydrogen/deuterium exchange (H/D exchange) experiments is an effective method for characterizing protein dynamics, and protein-protein or protein-ligand interactions. Despite methodological...
5.
Tamvakopoulos C, Neugebauer J, Donnelly M, Griffin P
J Chromatogr B Analyt Technol Biomed Life Sci
. 2002 Jul;
776(2):161-8.
PMID: 12137997
A method is described for the determination of betamethasone in rat plasma by liquid chromatography-tandem mass spectrometry (LC-MS-MS). The analyte was recovered from plasma by solid-phase extraction and subsequently analyzed...
6.
Roy R, Yang P, Kodali S, Xiong Y, Kim R, Griffin P, et al.
Chem Biol
. 2001 Dec;
8(11):1095-106.
PMID: 11731300
Background: The glycopeptide antibiotic vancomycin complexes DAla-DAla termini of bacterial cell walls and peptidoglycan precursors and interferes with enzymes involved in murein biosynthesis. Semisynthetic vancomycins incorporating hydrophobic sugar substituents exhibit...
7.
Poon G, Chen Q, Teffera Y, Ngui J, Griffin P, Braun M, et al.
Drug Metab Dispos
. 2001 Nov;
29(12):1608-13.
PMID: 11717180
The metabolism of diclofenac has been reported to produce reactive benzoquinone imine intermediates. We describe the identification of mercapturic acid derivatives of diclofenac in rats and humans. Three male Sprague-Dawley...
8.
Smith R, Griffin P, Xu Y, Smith A, Liu K, Calacay J, et al.
Biochem Biophys Res Commun
. 2000 Oct;
276(3):1306-13.
PMID: 11027627
The growth hormone secretagogue receptor (GHS-R) is involved in the regulation of pulsatile GH release. However, until recently, natural endogenous ligands for the receptor were unknown. We fractionated porcine hypothalamic...
9.
Tamvakopoulos C, Colwell L, Barakat K, Fenyk-Melody J, Griffin P, Nargund R, et al.
Rapid Commun Mass Spectrom
. 2000 Sep;
14(19):1729-35.
PMID: 11006579
A method is described for the evaluation of drug concentrations in plasma and brain from treated rats. The analyte is recovered from plasma or brain homogenate by liquid-liquid extraction and...
10.
Carmen A, Griffin P, Calaycay J, Rundlett S, Suka Y, Grunstein M
Proc Natl Acad Sci U S A
. 1999 Oct;
96(22):12356-61.
PMID: 10535926
Histone deacetylases such as human HDAC1 and yeast RPD3 are trichostatin A (TSA)-sensitive enzymes that are members of large, multiprotein complexes. These contain specialized subunits that help target the catalytic...