P R Dunbar
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Explore the profile of P R Dunbar including associated specialties, affiliations and a list of published articles.
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42
Citations
2197
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Recent Articles
1.
Raynes J, Frost H, Williamson D, Young P, Baker E, Steemson J, et al.
Front Microbiol
. 2016 Aug;
7:1119.
PMID: 27499748
Acute rheumatic fever (ARF) is an autoimmune response to Group A Streptococcus (GAS) infection. Repeated GAS exposures are proposed to 'prime' the immune system for autoimmunity. This notion of immune-priming...
2.
Henare K, Wang L, Wang L, Thomsen L, Tijono S, Chen C, et al.
Br J Cancer
. 2012 Mar;
106(6):1134-47.
PMID: 22415295
Background: The non-malignant cells of the tumour stroma have a critical role in tumour biology. Studies dissecting the interplay between cancer cells and stromal cells are required to further our...
3.
Graham E, Angel C, Schwarcz L, Dunbar P, Glass M
Int J Immunopathol Pharmacol
. 2010 Apr;
23(1):25-34.
PMID: 20377992
It is commonly accepted from gene expression studies that the CB2 receptor is expressed by most cell types of the rodent and human immune system. However, the exact identity of...
4.
Salio M, Shepherd D, Dunbar P, Palmowski M, Murphy K, Wu L, et al.
J Immunol
. 2001 Jul;
167(3):1188-97.
PMID: 11466333
Priming of melan-A(26/27-35)-specific CTL occurs only in a fraction of late stage melanoma patients, whereas during the early stages of the disease and in healthy volunteers, melan-A CTL have functional...
5.
Purbhoo M, Boulter J, Price D, Vuidepot A, Hourigan C, Dunbar P, et al.
J Biol Chem
. 2001 Jul;
276(35):32786-92.
PMID: 11438524
Recognition of antigen by cytotoxic T lymphocytes (CTL) is determined by interaction of both the T cell receptor and its CD8 coreceptor with peptide-major histocompatibility complex (pMHC) class I molecules....
6.
Xu X, Purbhoo M, Chen N, Mongkolsapaya J, Cox J, Meier U, et al.
Immunity
. 2001 May;
14(5):591-602.
PMID: 11371361
In this study, we have compared the effector functions and fate of a number of human CTL clones in vitro or ex vivo following contact with variant peptides presented either...
7.
Tafuro S, Meier U, Dunbar P, Jones E, Layton G, Hunter M, et al.
Eur J Immunol
. 2001 Feb;
31(2):440-9.
PMID: 11180108
Engineered MHC-peptide targets capable of inducing recognition by CTL may prove useful in designing vaccines for infectious disease and cancer. We tested whether peptides directly linked to beta2-microglobulin (beta2m) could...
8.
Dunbar P, Smith C, Chao D, Salio M, Shepherd D, Mirza F, et al.
J Immunol
. 2000 Nov;
165(11):6644-52.
PMID: 11086110
In a significant proportion of melanoma patients, CTL specific for the melan-A(26/7-35) epitope can be detected in peripheral blood using HLA-A2/peptide tetramers. However, the functional capacity of these CTL has...
9.
Strobel I, Krumbholz M, Menke A, Hoffmann E, Dunbar P, Bender A, et al.
Hum Gene Ther
. 2000 Nov;
11(16):2207-18.
PMID: 11084678
Dendritic cells (DCs) are the most potent inducers of immune reactions. Genetically modified DCs, which express tumor-associated antigens (TAA), can efficiently induce antitumor immunity and thus have a high potential...
10.
Tan L, Mowat A, Fazou C, Rostron T, Roskell H, Dunbar P, et al.
Arthritis Res
. 2000 Nov;
2(2):154-64.
PMID: 11062606
Introduction: Epstein-Barr virus (EBV) is transmitted orally, replicates in the oropharynx and establishes life-long latency in human B lymphocytes. T-cell responses to latent and lytic/replicative cycle proteins are readily detectable...