P N Tsichlis
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Explore the profile of P N Tsichlis including associated specialties, affiliations and a list of published articles.
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102
Citations
5199
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Recent Articles
1.
Kanellis D, Bursac S, Tsichlis P, Volarevic S, Eliopoulos A
Oncogene
. 2014 Jul;
34(19):2516-26.
PMID: 24998852
Tumor Progression Locus 2 (TPL2) is widely recognized as a cytoplasmic mitogen-activated protein 3 kinase with a prominent role in the regulation of inflammatory and oncogenic signal transduction. Herein we...
2.
Robinson M, Beinke S, Kouroumalis A, Tsichlis P, Ley S
Mol Cell Biol
. 2007 Aug;
27(21):7355-64.
PMID: 17709378
Tumor progression locus 2 (TPL-2) kinase is essential for Toll-like receptor 4 activation of the mitogen-activated protein kinase extracellular signal-regulated kinase (ERK) and for upregulation of the inflammatory cytokine tumor...
3.
Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling
Cittadini A, Monti M, Iaccarino G, Di Rella F, Tsichlis P, Di Gianni A, et al.
Gene Ther
. 2005 Aug;
13(1):8-19.
PMID: 16094411
The serine-threonine kinase Akt/PKB mediates stimuli from different classes of cardiomyocyte receptors, including the growth hormone/insulin like growth factor and the beta-adrenergic receptors. Whereas the growth-promoting and antiapoptotic properties of...
4.
Chan T, Tsichlis P
Sci STKE
. 2001 Dec;
2001(66):pe1.
PMID: 11752635
The kinase Akt contains two phosphatidylinositol-3 kinase (PI3K)-dependent phosphorylation sites, one in the activation loop (Thr(308)) and one in the carboxyl-terminal tail (Ser(473)), both of which are conserved among the...
5.
Malstrom S, Tili E, Kappes D, Ceci J, Tsichlis P
Proc Natl Acad Sci U S A
. 2001 Dec;
98(26):14967-72.
PMID: 11752445
Transgenic mice expressing MyrAkt from a proximal Lck promoter construct develop thymomas at an early age, whereas transgenic mice expressing constitutively active Lck-AktE40K develop primarily tumors of the peripheral lymphoid...
6.
Sun M, Wang G, Paciga J, Feldman R, Yuan Z, Ma X, et al.
Am J Pathol
. 2001 Aug;
159(2):431-7.
PMID: 11485901
Extensive studies have demonstrated that the Akt/AKT1 pathway is essential for cell survival and inhibition of apoptosis; however, alterations of Akt/AKT1 in human primary tumors have not been well documented....
7.
Mende I, Malstrom S, Tsichlis P, Vogt P, Aoki M
Oncogene
. 2001 Jul;
20(32):4419-23.
PMID: 11466625
The kinases Akt2, Akt3 and their myristylated variants, Myr-Akt2 and Myr-Akt3 were expressed by the RCAS vector in chicken embryo fibroblasts (CEF). Myr-Akt2 and Myr-Akt3 were strongly oncogenic, inducing multilayered...
8.
Patriotis C, Russeva M, Lin J, Srinivasula S, Markova D, Tsatsanis C, et al.
J Cell Physiol
. 2001 Mar;
187(2):176-87.
PMID: 11267997
The Tpl-2 proto-oncoprotein promotes cellular proliferation when overexpressed in a variety of tumor cell lines. Here, we present evidence that when overexpressed in immortalized non-transformed cells, Tpl-2 induces apoptosis by...
9.
Dumitru C, Ceci J, Tsatsanis C, Kontoyiannis D, Stamatakis K, Lin J, et al.
Cell
. 2001 Feb;
103(7):1071-83.
PMID: 11163183
Tpl2 knockout mice produce low levels of TNF-alpha when exposed to lipopolysaccharide (LPS) and they are resistant to LPS/D-Galactosamine-induced pathology. LPS stimulation of peritoneal macrophages from these mice did not...
10.
Poyet J, Srinivasula S, Lin J, Fernandes-Alnemri T, Yamaoka S, Tsichlis P, et al.
J Biol Chem
. 2000 Sep;
275(48):37966-77.
PMID: 10980203
To understand the mechanism of activation of the IkappaB kinase (IKK) complex in the tumor necrosis factor (TNF) receptor 1 pathway, we examined the possibility that oligomerization of the IKK...