P N Tsichlis
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Explore the profile of P N Tsichlis including associated specialties, affiliations and a list of published articles.
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102
Citations
5199
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Recent Articles
11.
De Vita G, Berlingieri M, Visconti R, Castellone M, Viglietto G, Baldassarre G, et al.
Cancer Res
. 2000 Aug;
60(14):3916-20.
PMID: 10919669
The Akt/protein kinase B serine/threonine kinase is a downstream effector of phosphoinositide 3-kinase (PI3K). Akt is an important component of mitogenic and antiapoptotic signaling pathways and is implicated in neoplastic...
12.
De Vita G, Melillo R, Carlomagno F, Visconti R, Castellone M, Bellacosa A, et al.
Cancer Res
. 2000 Aug;
60(14):3727-31.
PMID: 10919641
The RET tyrosine kinase is a functional receptor for neurotrophic ligands of the glial cell line-derived neurotrophic factor (GDNF) family. Loss of function of RET is associated with congenital megacolon...
13.
Chan T, Rittenhouse S, Tsichlis P
Annu Rev Biochem
. 2000 Jun;
68:965-1014.
PMID: 10872470
The protein kinase Akt/PKB is activated via a multistep process by a variety of signals. In the early steps of this process, PI-3 kinase-generated D3-phosphorylated phosphoinositides bind the Akt PH...
14.
Kampranis S, Damianova R, Atallah M, Toby G, Kondi G, Tsichlis P, et al.
J Biol Chem
. 2000 Jun;
275(38):29207-16.
PMID: 10859306
The mammalian inducer of apoptosis Bax is lethal when expressed in yeast and plant cells. To identify potential inhibitors of Bax in plants we transformed yeast cells expressing Bax with...
15.
Osada M, Tolkacheva T, Li W, Chan T, Tsichlis P, Saez R, et al.
Mol Cell Biol
. 1999 Aug;
19(9):6333-44.
PMID: 10454580
Multiple biological functions have been ascribed to the Ras-related G protein R-Ras. These include the ability to transform NIH 3T3 fibroblasts, the promotion of cell adhesion, and the regulation of...
16.
Srinivasula S, Ahmad M, Lin J, Poyet J, Fernandes-Alnemri T, Tsichlis P, et al.
J Biol Chem
. 1999 Jun;
274(25):17946-54.
PMID: 10364242
Molecules that regulate NF-kappaB activation play critical roles in apoptosis and inflammation. We describe the cloning of the cellular homolog of the equine herpesvirus-2 protein E10 and show that both...
17.
Lin J, Makris A, McMahon C, BEAR S, Patriotis C, Prasad V, et al.
J Biol Chem
. 1999 May;
274(21):14706-15.
PMID: 10329666
Tvl-1 is a 269-amino acid ankyrin repeat protein expressed primarily in thymus, lung, and testes that was identified by screening a murine T-cell two-hybrid cDNA library for proteins that associate...
18.
Kurowski T, Lin Y, Luo Z, Tsichlis P, BUSE M, Heydrick S, et al.
Diabetes
. 1999 Mar;
48(3):658-63.
PMID: 10078574
Sustained hyperglycemia impairs insulin-stimulated glucose utilization in the skeletal muscle of both humans and experimental animals--a phenomenon referred to clinically as glucose toxicity. To study how this occurs, a model...
19.
Grammatikakis N, Lin J, Grammatikakis A, Tsichlis P, Cochran B
Mol Cell Biol
. 1999 Feb;
19(3):1661-72.
PMID: 10022854
Genetic screens in Drosophila have identified p50(cdc37) to be an essential component of the sevenless receptor/mitogen-activated kinase protein (MAPK) signaling pathway, but neither the function nor the target of p50(cdc37)...
20.
Tsatsanis C, Patriotis C, Tsichlis P
Oncogene
. 1998 Dec;
17(20):2609-18.
PMID: 9840924
The Tpl-2 kinase activates the nuclear factor of activated T cells (NFAT) and induces IL-2 expression in T-cell lines. Here we show that the activation of the IL-2 promoter by...