P N Palma
Overview
Explore the profile of P N Palma including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
11
Citations
157
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Bonifacio M, Torrao L, Loureiro A, Palma P, Wright L, Soares-da-Silva P
Br J Pharmacol
. 2014 Nov;
172(7):1739-52.
PMID: 25409768
Background And Purpose: Catechol-O-methyltransferase (COMT) is an important target in the levodopa treatment of Parkinson's disease; however, the inhibitors available have problems, and not all patients benefit from their efficacy....
2.
Palma P, Rodrigues M, Archer M, Bonifacio M, Loureiro A, Learmonth D, et al.
Mol Pharmacol
. 2006 Apr;
70(1):143-53.
PMID: 16618795
In this work, we present a comparative case study of "ortho-" and "meta-nitrated" catecholic inhibitors of catechol-O-methyltransferase (COMT), with regard to their interaction with the catalytic site of the enzyme...
3.
Palma P, Bonifacio M, Loureiro A, Wright L, Learmonth D, Soares-da-Silva P
Drug Metab Dispos
. 2003 Feb;
31(3):250-8.
PMID: 12584150
Catechol-O-methyltransferase (COMT, EC 2.1.1.6) plays a central role in the metabolic inactivation of neurotransmitters and neuroactive xenobiotics possessing a catechol motif. 1-(3,4-Dihydroxy-5-nitrophenyl)-2-phenyl-ethanone (BIA 3-202) is a novel nitrocatechol-type inhibitor of...
4.
Morelli X, Palma P, Guerlesquin F, Rigby A
Protein Sci
. 2001 Sep;
10(10):2131-7.
PMID: 11567104
We present a novel and efficient approach for assessing protein-protein complex formation, which combines ab initio docking calculations performed with the protein docking algorithm BiGGER and chemical shift perturbation data...
5.
Palma P, Krippahl L, Wampler J, Moura J
Proteins
. 2000 May;
39(4):372-84.
PMID: 10813819
A new computationally efficient and automated "soft docking" algorithm is described to assist the prediction of the mode of binding between two proteins, using the three-dimensional structures of the unbound...
6.
Morelli X, Dolla A, Czjzek M, Palma P, Blasco F, Krippahl L, et al.
Biochemistry
. 2000 Mar;
39(10):2530-7.
PMID: 10704202
The combination of docking algorithms with NMR data has been developed extensively for the studies of protein-ligand interactions. However, to extend this development for the studies of protein-protein interactions, the...
7.
Pettigrew G, Gilmour R, Goodhew C, Hunter D, Devreese B, Van Beeumen J, et al.
Eur J Biochem
. 1999 Jan;
258(2):559-66.
PMID: 9874223
The implications of the dimeric state of cytochrome c550 for its binding to Paracoccus cytochrome c peroxidase and its delivery of the two electrons required to restore the active enzyme...
8.
Morais J, Palma P, Frazao C, Caldeira J, LeGall J, Moura I, et al.
Biochemistry
. 1995 Oct;
34(39):12830-41.
PMID: 7548038
The three-dimensional X-ray structure of cytochrome c3 from a sulfate reducing bacterium, Desulfovibrio desulfuricans ATCC 27774 (107 residues, 4 heme groups), has been determined by the method of molecular replacement...
9.
Palma P, Moura I, LeGall J, Van Beeumen J, Wampler J, Moura J
Biochemistry
. 1994 May;
33(21):6394-407.
PMID: 8204572
Small electron-transfer proteins such as flavodoxin (16 kDa) and the tetraheme cytochrome c3 (13 kDa) have been used to mimic, in vitro, part of the complex electron-transfer chain operating between...
10.
Caldeira J, Palma P, Regalla M, Lampreia J, Calvete J, Schafer W, et al.
Eur J Biochem
. 1994 Mar;
220(3):987-95.
PMID: 8143752
Flavodoxin was isolated and purified from Desulfovibrio desulfuricans ATCC 27774, a sulfate-reducing organism that can also utilize nitrate as an alternative electron acceptor. Mid-point oxidation-reduction potentials of this flavodoxin were...