P N MAGEE
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Explore the profile of P N MAGEE including associated specialties, affiliations and a list of published articles.
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Articles
149
Citations
1593
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Recent Articles
1.
Fong L, Nguyen V, Pegg A, MAGEE P
Cancer Epidemiol Biomarkers Prev
. 2001 Apr;
10(3):191-9.
PMID: 11303587
Alpha-difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase, the first enzyme in polyamine synthesis. Previous work showed simultaneous administration of DFMO and a zinc-deficient (ZD) diet to weanling rats...
2.
Fong L, Nguyen V, Farber J, Huebner K, MAGEE P
Cancer Res
. 2000 Sep;
60(16):4589-95.
PMID: 10969811
The p16ink4a-cyclin D1/cyclin-dependent kinase 4 (Cdk4)-retinoblastoma (Rb) pathway has emerged as a critical target in oncogenesis. The zinc-deficient (ZD), N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal cancer model provides a tool to study...
3.
Fong L, MAGEE P
Cancer Lett
. 1999 Aug;
143(1):63-9.
PMID: 10465339
The effect of zinc deficiency on N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumor formation in rats has been well documented. Our previous work showed that zinc deficiency and its associated increased esophageal cell...
4.
Fong L, Pegg A, MAGEE P
Cancer Res
. 1998 Dec;
58(23):5380-8.
PMID: 9850069
Sustained, increased cell proliferation induced by dietary zinc deficiency in rats plays a critical role in esophageal carcinogenesis. It is the determining factor that converts an otherwise nontumorigenic dose of...
5.
Fong L, Farber J, MAGEE P
Carcinogenesis
. 1998 Oct;
19(9):1591-6.
PMID: 9771929
Previous work has shown that sustained increased and decreased cell proliferation, induced by dietary zinc deficiency and caloric restriction respectively, influence the course of N-nitrosomethylbenzylamine (NMBA)-induced esophageal carcinogenesis in rats....
6.
Fong L, Lau K, Huebner K, MAGEE P
Carcinogenesis
. 1997 Aug;
18(8):1477-84.
PMID: 9276619
Dietary zinc deficiency in rats induces hyperplasia in the esophagus and increases N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumor incidence. Previous work showed a direct relationship between epithelial cell proliferation and esophageal tumor...
7.
8.
Fong L, Li J, Farber J, MAGEE P
Carcinogenesis
. 1996 Sep;
17(9):1841-8.
PMID: 8824504
Target cell proliferation was investigated throughout the development of esophageal cancer induced by N-nitroso-methylbenzylamine (NMBA) in weanling rats maintained on zinc-deficient or sufficient diets. Deficient rats were fed ad libitum,...
9.
Anderson L, Koseniauskas R, Burak E, Logsdon D, Carter J, Driver C, et al.
Drug Metab Dispos
. 1994 Jan;
22(1):43-9.
PMID: 8149888
Oral cotreatment of mice with ethanol results in increased tumors in extrahepatic organs caused by some nitrosamines. This action, attributed in part to inhibition of hepatic first-pass carcinogen metabolism by...
10.
Fong L, Bevill R, Thurmon J, MAGEE P
Carcinogenesis
. 1992 Nov;
13(11):2153-9.
PMID: 1423888
Procarbazine (PCZ), an antineoplastic agent that produces methylated bases in DNA after metabolic activation, has been implicated in the development of secondary cancers in patients treated for a primary neoplasm....