P M Sexton
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Explore the profile of P M Sexton including associated specialties, affiliations and a list of published articles.
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62
Citations
1127
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Recent Articles
1.
Furness S, Christopoulos A, Sexton P, Wootten D
Biochem Pharmacol
. 2018 Aug;
156:223-240.
PMID: 30149018
The glucagon-like peptide 1 receptor (GLP-1R) can be activated by a number of endogenous peptide hormones, including extended, processed, glycine extended and carboxy-terminally amidated versions of glucagon-like peptide 1 (GLP-1)....
2.
Miller L, Sexton P, Dong M, Harikumar K
Int J Obes Suppl
. 2016 May;
4(Suppl 1):S9-S13.
PMID: 27152167
Glucagon-like peptide-1 (GLP-1) is a gastrointestinal hormone secreted from L cells in the distal small intestine and proximal colon after a meal that acts as an incretin to augment the...
3.
Cook A, Mistry S, Gregory K, Furness S, Sexton P, Scammells P, et al.
Br J Pharmacol
. 2014 Sep;
172(1):185-200.
PMID: 25220431
Background And Purpose: Clinical use of cinacalcet in hyperparathyroidism is complicated by its tendency to induce hypocalcaemia, arising partly from activation of calcium-sensing receptors (CaS receptors) in the thyroid and...
4.
Alexander S, Benson H, Faccenda E, Pawson A, Sharman J, McGrath J, et al.
Br J Pharmacol
. 2014 Feb;
170(8):1449-58.
PMID: 24528237
The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of...
5.
Leach K, Sexton P, Christopoulos A, Conigrave A
Br J Pharmacol
. 2013 Oct;
171(5):1142-55.
PMID: 24111791
The human calcium-sensing receptor (CaSR) is widely expressed in the body, where its activity is regulated by multiple orthosteric and endogenous allosteric ligands. Each ligand stabilizes a unique subset of...
6.
Dong M, Koole C, Wootten D, Sexton P, Miller L
Br J Pharmacol
. 2013 Jul;
171(5):1085-101.
PMID: 23889342
Class B guanine nucleotide-binding protein GPCRs share heptahelical topology and signalling via coupling with heterotrimeric G proteins typical of the entire superfamily of GPCRs. However, they also exhibit substantial structural...
7.
Evidence for a new subclass of calcitonin/ calcitonin gene-related peptide binding site in rat brain
Sexton P, McKenzie J, Mendelsohn F
Neurochem Int
. 2010 May;
12(3):323-35.
PMID: 20501235
Binding sites for calcitonin and calcitonin gene-related peptide are widely distributed in the central nervous system. In this study, binding of [(125)I]-alpha-rat calcitonin gene-related peptide and [(125)I]-salmon calcitonin in adjacent...
8.
Sexton P
Curr Opin Drug Discov Devel
. 2009 Aug;
2(5):440-8.
PMID: 19649971
The family B or class II group of G-protein coupled receptors encompasses receptors for peptide hormones including secretin, vasoactive intestinal polypeptide, glucagon, parathyroid hormone and calcitonin. Receptor activity modifying proteins...
9.
Espallergues J, Lapalud P, Christopoulos A, Avlani V, Sexton P, Vamvakides A, et al.
Br J Pharmacol
. 2007 Jul;
152(2):267-79.
PMID: 17641675
Background And Purpose: Tetrahydro-N, N-dimethyl-5, 5-diphenyl-3-furanmethanamine hydrochloride (ANAVEX1-41) is a potent muscarinic and sigma(1) (sigma (1)) receptor ligand. The sigma (1) receptor modulates glutamatergic and cholinergic responses in the forebrain...
10.
Bisson W, Cheltsov A, Bruey-Sedano N, Lin B, Chen J, Goldberger N, et al.
Proc Natl Acad Sci U S A
. 2007 Jul;
104(29):11927-32.
PMID: 17606915
Finding good drug leads de novo from large chemical libraries, real or virtual, is not an easy task. High-throughput screening is often plagued by low hit rates and many leads...