P M Sexton
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Explore the profile of P M Sexton including associated specialties, affiliations and a list of published articles.
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62
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1127
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Recent Articles
11.
van der Westhuizen E, Summers R, Halls M, Bathgate R, Sexton P
Curr Drug Targets
. 2007 Feb;
8(1):91-104.
PMID: 17266534
Relaxin was discovered more than 75 years prior to the identification of the receptors that mediate its actions. There has been a slow emergence in understanding the role of relaxin,...
12.
Christopoulos A, May L, Avlani V, Sexton P
Biochem Soc Trans
. 2004 Oct;
32(Pt 5):873-7.
PMID: 15494038
Allosteric modulators of G-protein-coupled receptors interact with binding sites that are topographically distinct from the orthosteric site recognized by the receptor's endogenous agonist. Allosteric ligands offer a number of advantages...
13.
Hay D, Christopoulos G, Christopoulos A, Sexton P
Biochem Soc Trans
. 2004 Oct;
32(Pt 5):865-7.
PMID: 15494035
Several receptors which bind the hormone AMY (amylin) with high affinity have now been identified. The minimum binding unit is composed of the CT (calcitonin) receptor at its core, plus...
14.
Blin-Wakkach C, Wakkach A, Sexton P, Rochet N, Carle G
Leukemia
. 2004 Jul;
18(9):1505-11.
PMID: 15284856
Infantile malignant osteopetrosis (IMO) is a rare and lethal disease characterized by an absence of bone resorption due to inactive OCLs. Affected patients display an increased bone mass and hematological...
15.
May L, Avlani V, Sexton P, Christopoulos A
Curr Pharm Des
. 2004 Jul;
10(17):2003-13.
PMID: 15279541
G protein-coupled receptors (GPCRs) constitute the largest receptor superfamily in the human genome and represent the most common targets of drug action. Classic agonist and antagonist ligands that act at...
16.
Paxinos G, Chai S, Christopoulos G, Huang X, Toga A, Wang H, et al.
J Chem Neuroanat
. 2004 Jul;
27(4):217-36.
PMID: 15261329
Calcitonin (CT) and amylin are related peptides with potent central actions, including suppression of appetite and gastric acid secretion. Little is known about the distribution and binding characteristics of amylin...
17.
Purdue B, Tilakaratne N, Sexton P
Recept Channels
. 2003 Jan;
8(3-4):243-55.
PMID: 12529940
The peptide hormone calcitonin is widely used therapeutically in the treatment of bone disorders such as Paget's disease, osteoporosis, and the hypercalcemia of some malignancies. However, emerging evidence suggests the...
18.
Sexton P, Albiston A, Morfis M, Tilakaratne N
Cell Signal
. 2001 Mar;
13(2):73-83.
PMID: 11257451
Our understanding of G protein-coupled receptor (GPCR) function has recently expanded to encompass novel protein interactions that underlie both cell-surface receptor expression and the exhibited phenotype. The most notable examples...
19.
Ellis T, Cudkowicz M, Sexton P, Growdon J
J Neuropsychiatry Clin Neurosci
. 2000 Aug;
12(3):364-9.
PMID: 10956570
The authors compared efficacy and safety of risperidone and clozapine for the treatment of psychosis in a double-blind trial with 10 subjects with Parkinson's disease (PD) and psychosis. Mean improvement...
20.
Tilakaratne N, Christopoulos G, Zumpe E, Foord S, Sexton P
J Pharmacol Exp Ther
. 2000 Jun;
294(1):61-72.
PMID: 10871296
Receptor activity modifying proteins (RAMPs) constitute a group of three proteins, designated as RAMP1, 2, and 3, which are able to effect functional changes in some members of the G...