P L Stanley
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Explore the profile of P L Stanley including associated specialties, affiliations and a list of published articles.
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9
Citations
111
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Recent Articles
1.
Burke J, Davern L, Stanley P, Gregor K, Banville J, Remillard R, et al.
J Pharmacol Exp Ther
. 2001 Jun;
298(1):376-85.
PMID: 11408565
Cytosolic phospholipase A2 (cPLA2) catalyzes the selective release of arachidonic acid from the sn-2 position of phospholipids and is believed to play a key cellular role in the generation of...
2.
SPRINGER D, Luh B, Bronson J, McElhone K, Mansuri M, Gregor K, et al.
Bioorg Med Chem
. 2000 Jul;
8(5):1087-109.
PMID: 10882020
Twenty-four hydrophobic dicarboxylic acids are described which were evaluated as inhibitors of 14 kDa human platelet phospholipase A2 (HP-PLA2). In general, biarylacetic acid derivatives were found to be more active...
3.
Tramposch K, Chilton F, Stanley P, Franson R, Havens M, Nettleton D, et al.
J Pharmacol Exp Ther
. 1994 Nov;
271(2):852-9.
PMID: 7965805
The effect of a phospholipase A2 (PLA2) inhibitor on leukotriene, prostaglandin and platelet activating factor (PAF) biosynthesis in isolated cells and in vivo was determined. BMS-181162, [4(3'-carboxyphenyl)-3,7-dimethyl-9(2",6",6"-trimethyl-1"- cyclohexenyl)2Z,4E,6E,8E-nonatetraenoic acid], reversibly...
4.
Stanley P, Diaz P, Bailey M, Gygi D, Juarez A, Hughes C
Mol Microbiol
. 1993 Nov;
10(4):781-7.
PMID: 7934840
A transposon mutant of Escherichia coli 5K was isolated which reduced 10- to 50-fold the secreted extracellular haemolytic activity of cells carrying the complete hlyCABD operon while leaving unaffected the...
5.
Tramposch K, STEINER S, Stanley P, Nettleton D, Franson R, Lewin A, et al.
Biochem Biophys Res Commun
. 1992 Nov;
189(1):272-9.
PMID: 1449483
Activation of a phospholipase A2 (PLA2) is a key step in the production of precursors for the biosynthesis of lipid mediators of inflammation. Inhibition of this enzyme could result in...
6.
Alford J, Stanley P, Todderud G, Tramposch K
Agents Actions
. 1992 Nov;
37(3-4):260-7.
PMID: 1338267
We have previously shown that multiple topical applications, over 11 days, of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a persistent inflammatory reaction characterized by edema, cell infiltration and epidermal hyperplasia....
7.
Stanley P, Steiner S, Havens M, Tramposch K
Skin Pharmacol
. 1991 Jan;
4(4):262-71.
PMID: 1789987
It is well known that applications of a single dose of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse ears induces an acute inflammatory reaction consisting of erythema, edema and polymorphonuclear leukocyte (PMN) infiltration....
8.
Tramposch K, Zusi F, Marathe S, Stanley P, Nair X, STEINER S, et al.
Agents Actions
. 1990 Jun;
30(3-4):443-50.
PMID: 2117339
Drugs which block the biosynthesis of leukotrienes and prostaglandins may have potential in the treatment of psoriasis and other skin diseases. The biochemical and anti-inflammatory activity of 9-phenylnonanohydroxamic acid (BMY...
9.
Cross M, Koronakis V, Stanley P, Hughes C
J Bacteriol
. 1990 Mar;
172(3):1217-24.
PMID: 1689714
The synthesis and secretion of hemolysin (HlyA) by Escherichia coli are governed by four contiguous genes (hlyCABD) that are closely conserved on plasmids and, among human pathogenic strains, on the...