P L Harkonen
Overview
Explore the profile of P L Harkonen including associated specialties, affiliations and a list of published articles.
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Articles
35
Citations
656
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Recent Articles
1.
Kahkonen T, Toriseva M, Petruk N, Virta A, Maher A, Eigeliene N, et al.
Cell Oncol (Dordr)
. 2020 Oct;
44(1):205-218.
PMID: 33119860
Purpose: Fibroblast growth factor receptors (FGFR) and pathways are important players in breast cancer (BC) development. They are commonly altered, and BCs exhibiting FGFR gene amplification are currently being studied...
2.
Kahkonen T, Ivaska K, Jiang M, Buki K, Vaananen H, Harkonen P
Mol Cell Endocrinol
. 2017 Sep;
461:194-204.
PMID: 28923346
Fibroblast growth factors (FGF) and their receptors (FGFRs) regulate many developmental processes including differentiation of mesenchymal stromal cells (MSC). We developed two MSC lines capable of differentiating to osteoblasts and...
3.
Nilsson E, Brokken L, Narvi E, Kallio M, Harkonen P
Mol Cell Endocrinol
. 2012 Apr;
358(1):104-15.
PMID: 22465097
Fibroblast growth factor-8 (FGF-8) is implicated in the development and progression of breast cancer and its levels are frequently elevated in breast tumors. The mechanisms driving FGF-8-mediated tumorigenesis are not...
4.
Michael H, Harkonen P, Kangas L, Vaananen H, Hentunen T
Br J Pharmacol
. 2007 Apr;
151(3):384-95.
PMID: 17420779
Background And Purpose: Several selective oestrogen receptor modulators (SERMs) with oestrogen agonist effects in bone cells and without increased risk of breast and endometrial cancer have been developed. Here, we...
5.
Gu G, Hentunen T, Nars M, Harkonen P, Vaananen H
Apoptosis
. 2005 May;
10(3):583-95.
PMID: 15909120
Glucocorticoid-induced osteoporosis may be at least in part due to the increased apoptosis of osteocytes. To study the role of osteocyte apoptosis in glucocorticoid-induced osteoporosis, we isolated primary osteocytes from...
6.
Mulari M, Qu Q, Harkonen P, Vaananen H
Calcif Tissue Int
. 2004 May;
75(3):253-61.
PMID: 15148559
Bone remodeling involves old bone resorption by osteoclasts and new bone formation by osteoblasts. However, the precise cellular mechanisms underlying these consecutive events remain obscure. To address this question in...
7.
Vaananen K, Harkonen P
Ernst Schering Res Found Workshop
. 2002 Oct;
(40):55-64.
PMID: 12355728
No abstract available.
8.
Valve E, Ruohola J, Tasanen M, Glover J, Darbre P, Harkonen P
J Steroid Biochem Mol Biol
. 2001 Dec;
78(5):389-400.
PMID: 11738549
The Shionogi 115 (S115) mouse mammary tumor cells express the MMTV-specific 1.7 kb mRNA (orf) at a high level in the presence of androgens. In lymphoid cells the orf-gene encodes...
9.
FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells
Mattila M, Ruohola J, Valve E, Tasanen M, Seppanen J, Harkonen P
Oncogene
. 2001 Jun;
20(22):2791-804.
PMID: 11420691
Fibroblast growth factor 8 (FGF-8) is a secreted heparin-binding protein, which has transforming potential. Alternative splicing of the mouse Fgf-8 gene potentially codes for eight protein isoforms (a-h) which differ...
10.
Valve E, Nevalainen M, Nurmi M, Laato M, Martikainen P, Harkonen P
Lab Invest
. 2001 Jun;
81(6):815-26.
PMID: 11406643
Fibroblast growth factor 8 (FGF-8) is implicated in growth of prostate cancer. Alternative splicing of the human FGF-8 gene potentially allows coding for four protein isoforms (a, b, e, and...