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P L Bruijnzeel

Explore the profile of P L Bruijnzeel including associated specialties, affiliations and a list of published articles. Areas
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Articles 72
Citations 661
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Recent Articles
1.
de Groot D, Bierman E, Bruijnzeel P, Carpentier P, Kulig B, Lallement G, et al.
J Appl Toxicol . 2002 Mar; 21 Suppl 1:S57-65. PMID: 11920922
Poisoning with the potent nerve agent soman produces a cascade of central nervous system (CNS) effects characterized by severe convulsions and eventually death. In animals that survive a soman intoxication,...
2.
Elliott G, Vanwersch R, Bruijnzeel P
J Pharmacol Toxicol Methods . 2001 Jun; 44(3):453-9. PMID: 11395322
A method, which allows the automated registration of the scratching activity of the hind legs of a mouse for periods longer than 24 h, has been developed and validated. Aluminium...
3.
Riedl H, Thepen T, Bihari I, Bruijnzeel P, Bruijnzeel-Koomen C
J Allergy Clin Immunol . 2000 Oct; 106(4):737-43. PMID: 11031345
Background: Pharmacologic studies in atopic eczema (AE) are difficult to standardize. Patients with AE differ in the stage of their skin disease (acute, subacute, chronic). Objective: This study was designed...
4.
Gijbels M, Elliott G, HogenEsch H, Zurcher C, van den Hoven A, Bruijnzeel P
Exp Dermatol . 2000 Oct; 9(5):351-8. PMID: 11016856
Chronic proliferative dermatitis (cpd) is a spontaneous mutation in C57BL/Ka mice (cpdm/cpdm). The dermatitis is characterized by redness, hairloss, scaling, pruritus and histologically by epithelial hyperproliferation, infiltration of eosinophils, macrophages...
5.
Bruijnzeel P, Mudde G, Versluis C, van Ieperen-van Dijk A, Bihari I, Knol E, et al.
J Allergy Clin Immunol . 2000 May; 105(5):1008-16. PMID: 10808184
Background: Epicutaneous application of aeroallergens induces a positive atopy patch test (APT) response in about 50% of patients with atopic eczema (AE) and sensitization for these allergens. Objective: To elucidate...
6.
Philippens I, Melchers B, Roeling T, Bruijnzeel P
Behav Res Methods Instrum Comput . 2000 Apr; 32(1):173-9. PMID: 10758675
A number of neurobehavioral methods have been developed to test behavior in marmoset monkeys. These test systems are (1) the bungalow test, which quantifies spontaneous explorative behavior, (2) the hand-eye...
7.
van der Schans G, Haring R, Bruijnzeel P, den Daas N
J Androl . 2000 Mar; 21(2):250-7. PMID: 10714819
An immunochemical assay has been developed to detect oxidative damage in bovine sperm DNA. Sperm DNA contains a large amount of oxidative damage as a result of exposure to exogenous...
8.
Philippens I, Vanwersch R, Groen B, Olivier B, Bruijnzeel P, Melchers B
Toxicol Sci . 2000 Feb; 53(1):84-91. PMID: 10653525
Subchronic pretreatment with physostigmine (PHY) (0.0125 mg/kg/h) leading to a blood acetylcholinesterase inhibition of about 30% caused no side effects when applied to marmoset monkeys. This was evident on behavioral...
9.
Philippens I, Melchers B, Olivier B, Bruijnzeel P
Pharmacol Biochem Behav . 2000 Jan; 65(1):175-82. PMID: 10638651
The efficacy of the subchronically administered cholinesterase-inhibitor physostigmine (PHY) (0.025 mg/kg/h) either with or without the muscarinergic receptor antagonist scopolamine (SCO) (0.018 mg/kg/h) in counteracting soman-induced lethality and incapacitation were...
10.
van Helden H, Groen B, Moor E, Westerink B, Bruijnzeel P
Drug Chem Toxicol . 1999 Feb; 21 Suppl 1:171-81. PMID: 10028409
Current treatment of acute organophosphate (OP) poisoning includes a combined administration of a cholinesterase reactivator (oxime), a muscarinic receptor antagonist (atropine) and an anticonvulsant (diazepam). This treatment is not adequate...