B P Melchers
Overview
Explore the profile of B P Melchers including associated specialties, affiliations and a list of published articles.
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25
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96
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Recent Articles
1.
de Groot D, Bierman E, Bruijnzeel P, Carpentier P, Kulig B, Lallement G, et al.
J Appl Toxicol
. 2002 Mar;
21 Suppl 1:S57-65.
PMID: 11920922
Poisoning with the potent nerve agent soman produces a cascade of central nervous system (CNS) effects characterized by severe convulsions and eventually death. In animals that survive a soman intoxication,...
2.
Philippens I, Melchers B, Roeling T, Bruijnzeel P
Behav Res Methods Instrum Comput
. 2000 Apr;
32(1):173-9.
PMID: 10758675
A number of neurobehavioral methods have been developed to test behavior in marmoset monkeys. These test systems are (1) the bungalow test, which quantifies spontaneous explorative behavior, (2) the hand-eye...
3.
Philippens I, Vanwersch R, Groen B, Olivier B, Bruijnzeel P, Melchers B
Toxicol Sci
. 2000 Feb;
53(1):84-91.
PMID: 10653525
Subchronic pretreatment with physostigmine (PHY) (0.0125 mg/kg/h) leading to a blood acetylcholinesterase inhibition of about 30% caused no side effects when applied to marmoset monkeys. This was evident on behavioral...
4.
Philippens I, Melchers B, Olivier B, Bruijnzeel P
Pharmacol Biochem Behav
. 2000 Jan;
65(1):175-82.
PMID: 10638651
The efficacy of the subchronically administered cholinesterase-inhibitor physostigmine (PHY) (0.025 mg/kg/h) either with or without the muscarinergic receptor antagonist scopolamine (SCO) (0.018 mg/kg/h) in counteracting soman-induced lethality and incapacitation were...
5.
Philippens I, Busker R, Wolthuis O, Olivier B, Bruijnzeel P, Melchers B
Pharmacol Biochem Behav
. 1998 May;
59(4):1061-7.
PMID: 9586868
The behavioral and neurophysiological effects of the subchronically administered cholinesterase-inhibitor physostigmine (PHY) (0.025 mg/kg/h) either with or without the muscarinergic antagonist scopolamine (SCO) (0.018 mg/kg/h) were determined in guinea pigs....
6.
Philippens I, Olivier B, Melchers B
Pharmacol Biochem Behav
. 1998 Jan;
58(4):909-13.
PMID: 9408195
The effects of the acetylcholinesterase inhibitor physostigmine (PHY) on the auditory startle reflex in guinea pigs were studied. The dose-response curve of PHY appeared bell shaped, with a maximum effect...
7.
Busker R, Zijlstra J, Philippens I, Groen B, Melchers B
Toxicology
. 1996 Sep;
112(3):183-94.
PMID: 8845039
The therapeutic efficacy of single or repeated doses of HI-6, together with atropine, against soman poisoning were compared both in guinea pigs and in marmoset monkeys. In addition, the pharmacokinetics...
8.
Philippens I, Wolthuis O, Busker R, Langenberg J, Melchers B
Pharmacol Biochem Behav
. 1996 Sep;
55(1):99-105.
PMID: 8870044
To prevent incapacitation following nerve agent intoxications, it is proposed to replace pyridostigmine by the centrally active carbamate physostigmine (PHY). Behavioral and neurophysiological effects of PHY were determined and whether...
9.
van Helden H, Busker R, Melchers B, Bruijnzeel P
Arch Toxicol
. 1996 Jan;
70(12):779-86.
PMID: 8911635
The increased international concern about the threat of military and terroristic use of nerve agents, prompted us to critically consider the expected value of the currently available oxime treatment of...
10.
Roeling T, Docter G, Voorn P, Melchers B, Wolters E, Groenewegen H
J Chem Neuroanat
. 1995 Oct;
9(3):155-64.
PMID: 8588831
Previous immunocytochemical studies in rats have indicated that striatal dopamine depletion leads to an increase in enkephalin-immunoreactivity and a decrease in substance P-immunoreactivity in the striatum. Similar studies in primates...