P K Singal
Overview
Explore the profile of P K Singal including associated specialties, affiliations and a list of published articles.
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Articles
136
Citations
3001
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Recent Articles
1.
Araujo A, Schenkel P, Enzveiler A, Fernandes T, Partata W, Llesuy S, et al.
J Mol Endocrinol
. 2008 Sep;
41(6):423-30.
PMID: 18787053
This study was conducted to test whether oxidative stress activates the intracellular protein kinase B (AKT1) signaling pathway, which culminates with cardiac hypertrophy in experimental hyperthyroidism. Male Wistar rats were...
2.
Lincoln D, Singal P, Al-Banaw A
Anticancer Res
. 2008 Jan;
27(6B):4201-18.
PMID: 18225592
Vascular tumours are common lesions of the skin and subcutaneous tissue, but also occur in many other tissues and internal organs. The well-differentiated tumours consist of irregular anastomosing, blood-filled vascular...
3.
Activation of apoptotic processes during transition from hypertrophy to heart failure in guinea pigs
Sharma A, Dhingra S, Khaper N, Singal P
Am J Physiol Heart Circ Physiol
. 2007 Jul;
293(3):H1384-90.
PMID: 17616743
Changes in oxidative stress and apoptotic process were studied during the progression of a compensated hypertrophy to a decompensated heart failure in guinea pigs. Banding of the ascending aorta resulted...
4.
Kaur K, Sharma A, Singal P
Am J Physiol Heart Circ Physiol
. 2006 Feb;
291(1):H106-13.
PMID: 16461369
We tested whether a decrease in the ratio of interleukin-10 (IL-10) to tumor necrosis factor-alpha (TNF-alpha) correlates with the decrease in cardiac function in heart failure. It has been suggested...
5.
Lou H, Danelisen I, Singal P
Am J Physiol Heart Circ Physiol
. 2005 Mar;
288(4):H1925-30.
PMID: 15772336
The current study investigated the phosphorylation of mitogen-activated protein kinases (MAPKs) as well as pro- and anti-apoptotic proteins in adriamycin (ADR)-induced cardiomyopathy (AIC) and heart failure in rats. Modulatory effects...
6.
Lou H, Danelisen I, Singal P
J Mol Cell Cardiol
. 2004 May;
36(5):683-90.
PMID: 15135663
Heart failure due to a variety of causes is accompanied by an upregulation of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6). Adriamycin-induced cardiomyopathy (AIC) and...
7.
Khaper N, Kaur K, Li T, Farahmand F, Singal P
Mol Cell Biochem
. 2003 Oct;
251(1-2):9-15.
PMID: 14575298
Increased oxidative stress and reduction in antioxidant enzymes have been suggested to be involved in the pathophysiology of congestive heart failure subsequent to myocardial infarction (MI). The objective of the...
8.
Bello-Klein A, Bock P, Travacio M, Senna S, Llesuy S, de Bittencourt Jr P, et al.
Cardiovasc Toxicol
. 2002 Sep;
1(1):43-50.
PMID: 12213996
Rats were made hypertensive by the administration of the nitric oxide synthase inhibitor nitro-L-arginine (LNA, 2.74 mmol/L) in drinking water for 7 d. Hearts from hemodynamically assessed animals were analyzed...
9.
Singal P, Bello-Klein A, Farahmand F, Sandhawalia V
Adv Exp Med Biol
. 2002 Mar;
498:213-20.
PMID: 11900371
When the equilibrium between free-radical production and cellular antioxidant defences is disturbed in favour of more free radicals, it causes oxidative stress which can promote cellular injury. Oxidative stress has...
10.
Khaper N, Singal P
J Am Coll Cardiol
. 2001 Apr;
37(5):1461-6.
PMID: 11300462
Objectives: To examine whether blocking of the renin-angiotensin system (RAS) at the angiotensin II type 1 (AT1) receptor site is accompanied by changes in the oxidative stress parameters. Background: Congestive...