P J Vainio
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Explore the profile of P J Vainio including associated specialties, affiliations and a list of published articles.
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11
Citations
85
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Recent Articles
1.
Sandler C, Ekokoski E, Lindstedt K, Vainio P, Finel M, Sorsa T, et al.
Inflamm Res
. 2005 Sep;
54(7):304-12.
PMID: 16134060
Objective: To find novel inhibitors of mast cell function we have studied the effect of a potent, non-antimicrobial, chemically modified tetracycline, CMT-3 or COL-3, on key functions of mast cells....
2.
Vainio P, Tuominen R
Nicotine Tob Res
. 2001 Jun;
3(2):177-82.
PMID: 11403732
Cotinine is the major metabolite of nicotine. It has nicotine-like biological activity, but its potency is low. We studied cotinine binding to nicotinic receptors labelled with [3H]epibatidine. In membranes from...
3.
Tornquist K, Vainio P, Bjorklund S, Titievsky A, Dugue B, Tuominen R
Biochem J
. 2000 Sep;
351(Pt 1):47-56.
PMID: 10998346
Redox modulation participates in the regulation of intracellular free calcium concentration ([Ca(2+)](i)) in several cell types. In thyroid cells, including FRTL-5 cells, changes in [Ca(2+)](i) regulate several important functions, including...
4.
Ekokoski E, Dugue B, Vainio M, Vainio P, Tornquist K
J Cell Physiol
. 2000 Mar;
183(2):155-62.
PMID: 10737891
We investigated the mechanism of phospholipase A(2) (PLA(2)) activation in response to the P2 receptor agonist ATP in rat thyroid FRTL-5 cells. The PLA(2) activity was determined by measuring the...
5.
Vainio P, Tornquist K, Tuominen R
Toxicol Appl Pharmacol
. 2000 Mar;
163(2):183-7.
PMID: 10698676
Cotinine is the major metabolite of nicotine. It has some biological activity, but its pathophysiological effects are largely unclear. We studied whether cotinine initiates calcium transients or affects those induced...
6.
Vainio P, Viluksela M, Tuominen R
Pharmacol Toxicol
. 1998 Dec;
83(5):188-93.
PMID: 9834966
We studied the effects of cotinine, the major metabolite of nicotine, on nicotine-induced increase in [3H]phorbol dibutyrate binding, activation of protein kinase C and [3H]noradrenaline release in primary cultured bovine...
7.
Vainio P, Viluksela M, Tuominen R
J Auton Pharmacol
. 1998 Oct;
18(4):245-50.
PMID: 9788295
1. We studied the effect of cotinine, a slowly eliminated metabolite of nicotine, on protein kinase C (PKC) distribution and noradrenaline release in primary cultured bovine adrenal chromaffin cells. Changes...
8.
McMillian M, Vainio P, Tuominen R
J Neuropathol Exp Neurol
. 1997 Mar;
56(3):301-7.
PMID: 9056544
Microglial activation selectively kills certain neuron populations in mixed neuronal/glial cultures, which may prove useful for modeling neurodegenerative diseases such as Parkinson's disease. In mesencephalic mixed neuronal/glial cultures, microglial activation...
9.
Aarnisalo A, Vainio P, Mannisto P, Vasar E, Tuominen R
Neuroreport
. 1996 Sep;
7(13):2167-70.
PMID: 8930982
We have studied a possible role of cholecystokinin (CCK) in regulating adrenal medullary function. Caerulein (10(-10)-10(-7) M), a CCK receptor agonist, increased formation of inositol phosphates in primary cultured bovine...
10.
Viluksela M, Vainio P, Tuominen R
J Antimicrob Chemother
. 1996 Sep;
38(3):465-73.
PMID: 8889721
Cytotoxicity of erythromycin base, erythromycin estolate, erythromycin-11,12-cyclic carbonate, roxithromycin, clarithromycin and azithromycin was compared in cultured human non-malignant Chang liver cells using reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and cellular protein...