P J Ratcliffe
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Explore the profile of P J Ratcliffe including associated specialties, affiliations and a list of published articles.
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123
Citations
11142
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Recent Articles
1.
Thinnes C, Tumber A, Yapp C, Scozzafava G, Yeh T, Chan M, et al.
Chem Commun (Camb)
. 2015 Sep;
51(84):15458-61.
PMID: 26345662
There is interest in developing potent, selective, and cell-permeable inhibitors of human ferrous iron and 2-oxoglutarate (2OG) oxygenases for use in functional and target validation studies. The 3-component Betti reaction...
2.
Coleman M, Ratcliffe P
Curr Pharm Des
. 2009 Aug;
15(33):3904-7.
PMID: 19671041
Cellular and systemic oxygen homeostasis is regulated by an oxygen-sensitive signalling pathway centred on a transcription factor known as Hypoxia Inducible Factor (HIF). Regulation of HIF activity and protein stability...
3.
Smith T, Brooks J, Balanos G, Lappin T, Layton D, Leedham D, et al.
Adv Exp Med Biol
. 2007 Dec;
605:51-6.
PMID: 18085246
Intracellular responses to hypoxia are coordinated by the von Hippel-Lindau--hypoxia-inducible factor (VHL-HIF) transcriptional system. This study investigated the potential role of the VHL-HIF pathway in human systems-level physiology. Patients diagnosed...
4.
Lau K, Tian Y, Raval R, Ratcliffe P, Pugh C
Br J Cancer
. 2007 Mar;
96(8):1284-92.
PMID: 17387348
Inactivation of the von Hippel-Lindau tumour suppressor in renal cell carcinoma (RCC) leads to failure of proteolytic regulation of the alpha subunits of hypoxia-inducible factor (HIF), constitutive upregulation of the...
5.
Wykoff C, Sotiriou C, Cockman M, Ratcliffe P, Maxwell P, Liu E, et al.
Br J Cancer
. 2004 Mar;
90(6):1235-43.
PMID: 15026807
Gene expression analysis was performed on a human renal cancer cell line (786-0) with mutated VHL gene and a transfectant with wild-type VHL to analyse genes regulated by VHL and...
6.
Mayosi B, Keavney B, Kardos A, Davies C, Ratcliffe P, Farrall M, et al.
Eur Heart J
. 2002 Dec;
23(24):1963-71.
PMID: 12473259
Aims: To assess the heritability (i.e. relative contribution of genetic factors to the variability) of continuous measures of left ventricular hypertrophy determined by electrocardiography and echocardiography. Methods And Results: We...
7.
Turner K, Crew J, Wykoff C, Watson P, Poulsom R, Pastorek J, et al.
Br J Cancer
. 2002 Apr;
86(8):1276-82.
PMID: 11953885
Regulation by hypoxia may underlie the expression of vascular endothelial growth factor in bladder cancer. We have compared the distribution of vascular endothelial growth factor mRNA with a hypoxia marker,...
8.
Maxwell P, Pugh C, Ratcliffe P
Adv Exp Med Biol
. 2002 Apr;
502:365-76.
PMID: 11950150
Matching oxygen consumption and supply represents a fundamental challenge to multicellular organisms. HIF-1 is a transcription complex which is emerging as a key mediator of oxygen homeostasis. HIF-1 controls the...
9.
Mole D, Maxwell P, Pugh C, Ratcliffe P
IUBMB Life
. 2002 Jan;
52(1-2):43-7.
PMID: 11795592
Hypoxia-inducible factor (HIF) is central in coordinating many of the transcriptional adaptations to hypoxia. Composed of a heterodimer of alpha and beta subunits, the alpha subunit is rapidly degraded in...
10.
Wykoff C, Pugh C, Harris A, Maxwell P, Ratcliffe P
Novartis Found Symp
. 2001 Dec;
240:212-25; discussion 225-31.
PMID: 11727931
Regulation of the growth and metabolism of large organisms is tightly constrained by the need for precise oxygen homeostasis. Work on control of the haematopoietic growth factor erythropoietin has led...