P J Michael Deans
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Explore the profile of P J Michael Deans including associated specialties, affiliations and a list of published articles.
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15
Citations
314
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Recent Articles
1.
Seah C, Breen M, Rusielewicz T, Bader H, Xu C, Hunter C, et al.
Nat Neurosci
. 2024 Dec;
28(1):214.
PMID: 39633181
No abstract available.
2.
Garcia M, Retallick-Townsley K, Pruitt A, Davidson E, Dai Y, Fitzpatrick S, et al.
bioRxiv
. 2024 Sep;
PMID: 39229156
Over a hundred risk genes underlie risk for autism spectrum disorder (ASD) but the extent to which they converge on shared downstream targets to increase ASD risk is unknown. To...
3.
Fernando M, Fan Y, Zhang Y, Tokolyi A, Murphy A, Kammourh S, et al.
bioRxiv
. 2023 Nov;
PMID: 37961635
Given the large number of genes significantly associated with risk for neuropsychiatric disorders, a critical unanswered question is the extent to which diverse mutations --sometimes impacting the same gene-- will...
4.
Deans P, Brennand K
Cell Genom
. 2023 Sep;
3(9):100403.
PMID: 37719145
Zhang, Zhang, Forrest combine allele-specific open chromatin (ASoC) mapping and CRISPR-editing to evaluate the functional impact of schizophrenia risk variants on human neuronal gene expression, synaptic development, and function. In...
5.
Seah C, Breen M, Rusielewicz T, Bader H, Xu C, Hunter C, et al.
Nat Neurosci
. 2022 Oct;
25(11):1434-1445.
PMID: 36266471
Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to which genetic and environmental risk factors contribute to individual clinical outcomes is unknown. Here, we compared transcriptional...
6.
Bhat A, Irizar H, Couch A, Raval P, Duarte R, Polit L, et al.
Brain Behav Immun
. 2022 Jun;
105:82-97.
PMID: 35716830
Maternal immune activation (MIA) during prenatal development is an environmental risk factor for psychiatric disorders including schizophrenia (SZ). Converging lines of evidence from human and animal model studies suggest that...
7.
Gatford N, Deans P, Duarte R, Chennell G, Sellers K, Raval P, et al.
Hum Mol Genet
. 2021 Sep;
31(5):674-691.
PMID: 34542148
The cell-adhesion proteins neuroligin-3 and neuroligin-4X (NLGN3/4X) have well described roles in synapse formation. NLGN3/4X are also expressed highly during neurodevelopment. However, the role these proteins play during this period...
8.
Li A, Cartwright S, Yu A, Ho S, Schrode N, Deans P, et al.
STAR Protoc
. 2021 Jun;
2(2):100580.
PMID: 34151300
We describe a CRISPR inhibition (CRISPRi) protocol to repress endogenous gene expression (e.g., ) in human induced pluripotent stem cell-derived -induced glutamatergic neurons. CRISPRi enables efficient and precise gene repression...
9.
Dobrindt K, Hoagland D, Seah C, Kassim B, OShea C, Murphy A, et al.
Stem Cell Reports
. 2021 Feb;
16(3):505-518.
PMID: 33636110
The host response to SARS-CoV-2, the etiologic agent of the COVID-19 pandemic, demonstrates significant interindividual variability. In addition to showing more disease in males, the elderly, and individuals with underlying...
10.
Schrode N, Seah C, Deans P, Hoffman G, Brennand K
Nat Protoc
. 2021 Jan;
16(2):812-840.
PMID: 33432232
The mechanisms by which genetic risk variants interact with each other, as well as environmental factors, to contribute to complex genetic disorders remain unclear. We describe in detail our recently...