Michael B Fernando
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Explore the profile of Michael B Fernando including associated specialties, affiliations and a list of published articles.
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15
Citations
308
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Recent Articles
1.
Fernando M, Fan Y, Zhang Y, Tokolyi A, Murphy A, Kammourh S, et al.
bioRxiv
. 2023 Nov;
PMID: 37961635
Given the large number of genes significantly associated with risk for neuropsychiatric disorders, a critical unanswered question is the extent to which diverse mutations --sometimes impacting the same gene-- will...
2.
Rahman S, Dong P, Apontes P, Fernando M, Kosoy R, Townsley K, et al.
Nucleic Acids Res
. 2023 Oct;
51(20):11142-11161.
PMID: 37811875
The human brain is a complex organ comprised of distinct cell types, and the contribution of the 3D genome to lineage specific gene expression remains poorly understood. To decipher cell...
3.
LaMarca E, Saito A, Plaza-Jennings A, Espeso-Gil S, Hellmich A, Fernando M, et al.
bioRxiv
. 2023 Jul;
PMID: 37503149
Here, we construct genome-scale maps for R-loops, three-stranded nucleic acid structures comprised of a DNA/RNA hybrid and a displaced single strand of DNA, in the proliferative and differentiated zones of...
4.
Bendl J, Hauberg M, Girdhar K, Im E, Vicari J, Rahman S, et al.
Nat Neurosci
. 2022 Sep;
25(10):1366-1378.
PMID: 36171428
To characterize the dysregulation of chromatin accessibility in Alzheimer's disease (AD), we generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the superior temporal gyrus and entorhinal cortex...
5.
Dong P, Hoffman G, Apontes P, Bendl J, Rahman S, Fernando M, et al.
Nat Genet
. 2022 Sep;
54(10):1493-1503.
PMID: 36163279
Identification of risk variants for neuropsychiatric diseases within enhancers underscores the importance of understanding population-level variation in enhancer function in the human brain. Besides regulating tissue-specific and cell-type-specific transcription of...
6.
Fernando M, Brennand K
Cell Stem Cell
. 2022 Feb;
29(2):181-183.
PMID: 35120616
Aberrant migration of GABAergic interneurons during cortical neurodevelopment is implicated in Timothy Syndrome, yet the underlying mechanisms remain elusive. In this issue of Cell Stem Cell, Birey et al. model...
7.
De Los Angeles A, Fernando M, Hall N, Brennand K, Harrison P, Maher B, et al.
Biol Psychiatry
. 2021 Jun;
90(6):362-372.
PMID: 34176589
A key challenge in psychiatry research is the development of high-fidelity model systems that can be experimentally manipulated to explore and test pathophysiological mechanisms of illness. In this respect, the...
8.
Dobrindt K, Hoagland D, Seah C, Kassim B, OShea C, Murphy A, et al.
Stem Cell Reports
. 2021 Feb;
16(3):505-518.
PMID: 33636110
The host response to SARS-CoV-2, the etiologic agent of the COVID-19 pandemic, demonstrates significant interindividual variability. In addition to showing more disease in males, the elderly, and individuals with underlying...
9.
10.
Wang M, Li A, Sekiya M, Beckmann N, Quan X, Schrode N, et al.
Neuron
. 2020 Nov;
109(2):257-272.e14.
PMID: 33238137
To identify the molecular mechanisms and novel therapeutic targets of late-onset Alzheimer's Disease (LOAD), we performed an integrative network analysis of multi-omics profiling of four cortical areas across 364 donors...