P I Pradeepkumar
Overview
Explore the profile of P I Pradeepkumar including associated specialties, affiliations and a list of published articles.
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50
Citations
503
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Recent Articles
1.
Bagale S, Deshmukh P, Mandal S, Malvi H, Kondabagil K, Pradeepkumar P
J Org Chem
. 2025 Jan;
90(2):1159-1166.
PMID: 39752229
The DNA adducts formed by the alkenylbenzene natural products, safrole (SF) and methyleugenol (MEG) are primarily attributed to their reported carcinogenic properties. Herein, we report a concise strategy to access...
2.
Roy S, Majee P, Sudhakar S, Mishra S, Kalia J, Pradeepkumar P, et al.
Chem Sci
. 2024 May;
15(21):7982-7991.
PMID: 38817587
Understanding the structure and recognition of highly conserved regulatory segments of the integrated viral DNA genome that forms unique topologies can greatly aid in devising novel therapeutic strategies to counter...
3.
Bagale S, Deshmukh P, Lad S, Sudarsan A, Sudhakar S, Mandal S, et al.
J Org Chem
. 2024 May;
89(11):7680-7691.
PMID: 38739842
Safrole is a natural product present in many plants and plant products, including spices and essential oils. During cellular metabolism, it converts to a highly reactive trans-isosafrole (SF) intermediate that...
4.
Deshmukh P, Lad S, Sudarsan A, Sudhakar S, Aggarwal T, Mandal S, et al.
Biochemistry
. 2023 Jul;
62(16):2391-2406.
PMID: 37486230
The secondary metabolites of polypropanoids, methyleugenol (MEG), and estragole (EG), found in many herbs and spices, are commonly used as food flavoring agents and as ingredients in cosmetics. MEG and...
5.
Lad S, Upadhyay M, Thorat P, Nair D, Moseley G, Srivastava S, et al.
J Mol Biol
. 2023 Jun;
435(17):168188.
PMID: 37380013
Viruses are believed to be the obligate intracellular parasites that only carry genes essential for infecting and hijacking the host cell machinery. However, a recently discovered group of viruses belonging...
6.
Khatik S, Sudhakar S, Mishra S, Kalia J, Pradeepkumar P, Srivatsan S
Chem Sci
. 2023 Jun;
14(21):5627-5637.
PMID: 37265741
Paucity of efficient probes and small molecule ligands that can distinguish different G-quadruplex (GQ) topologies poses challenges not only in understanding their basic structure but also in targeting an individual...
7.
Sudhakar S, Barkau C, Chilamkurthy R, Barber H, Pater A, Moran S, et al.
J Biol Chem
. 2023 Apr;
299(5):104700.
PMID: 37059184
Ribonucleoproteins (RNPs) comprise one or more RNA and protein molecules that interact to form a stable complex, which commonly involves conformational changes in the more flexible RNA components. Here, we...
8.
Kumar S, Pany S, Sudhakar S, Singh S, Todankar C, Pradeepkumar P
Biochemistry
. 2022 Oct;
61(22):2546-2559.
PMID: 36314731
Preferential stabilization of G-quadruplex (G4) structures using small-molecule ligands has emerged as an effective approach to develop anticancer drugs. Herein, we report the synthesis of three indole-fused quindoline derivatives with...
9.
Kumar S, Sannapureddi R, Todankar C, Ramanathan R, Biswas A, Sathyamoorthy B, et al.
Biochemistry
. 2022 May;
61(11):1064-1076.
PMID: 35584037
G-Quadruplex (G4) structures play a pivotal role in diverse biological functions, including essential processes, such as telomere maintenance and gene regulation. G4 structures formed in functional regions of genomes are...
10.
Biswas A, Singh S, Todankar C, Sudhakar S, Pany S, Pradeepkumar P
Phys Chem Chem Phys
. 2022 Mar;
24(10):6238-6255.
PMID: 35229834
G-Quadruplexes (G4s) are four-stranded motifs formed by G-rich nucleic acid sequences. These structures harbor significant biological importance as they are involved in telomere maintenance, transcription, and translation. Owing to their...